Ige reactivity to milk components in dogs with cutaneous adverse food reactions

Hidekatsu Shimakura, Tadahiro Nasukawa, Jumpei Uchiyama, Ryosuke Sugimoto, Ichiro Imanishi, Sumire Oota, Keijiro Mizukami, Masato Fujimura, Masahiro Sakaguchi

Research output: Contribution to journalComment/debatepeer-review

1 Citation (Scopus)


We investigated the IgE reactivity to crude and purified milk antigens in the sera of 112 dogs with cutaneous adverse food reactions (CAFRs). Of the 112 dogs, 33 (29%) had specific IgE for crude milk antigens. In the dogs with milk-specific IgE, IgE reactivity to casein, bovine serum albumin (BSA), α-lactalbumin, β-lactoglobulin, and bovine IgG were 81%, 85%, 39%, 27%, and 35%, respectively. Casein and BSA may be important allergens in dogs with CAFRs. Some canine vaccines contain casein hydrolysate as a stabilizer and the pooled serum with anti-casein IgE showed IgE reactivity to the vaccines containing it. Information about IgE reactivity to casein in dogs with CAFRs could be useful for predicting adverse reactions to the vaccines including casein hydrolysate.

Original languageEnglish
Pages (from-to)1509-1512
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number10
Publication statusPublished - 2021
Externally publishedYes


  • Cow’s milk allergen
  • Cutaneous adverse food reaction
  • Dog
  • IgE
  • Vaccine

ASJC Scopus subject areas

  • General Veterinary


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