TY - JOUR
T1 - IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
AU - Mäkelä, M. J.
AU - Kanehiro, A.
AU - Borish, L.
AU - Dakhama, A.
AU - Loader, J.
AU - Joetham, A.
AU - Xing, Z.
AU - Jordana, M.
AU - Larsen, G. L.
AU - Gelfand, E. W.
PY - 2000/5/23
Y1 - 2000/5/23
N2 - Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti- inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.
AB - Cytokines play an important role in modulating inflammatory responses and, as a result, airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma because of its immunosuppressive and anti- inflammatory properties. In contrast to these suggestions, we demonstrate in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function. Reconstitution of these deficient mice with the IL-10 gene fully restores development of airway hyperresponsiveness comparable to control mice. These results identify an important role of IL-10, downstream of the inflammatory cascade, in regulating the tone of the airways after allergic sensitization and challenge.
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U2 - 10.1073/pnas.100118997
DO - 10.1073/pnas.100118997
M3 - Article
C2 - 10811896
AN - SCOPUS:12944267034
SN - 0027-8424
VL - 97
SP - 6007
EP - 6012
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11
ER -