IL-12 production from monocytes induced by stimulus via HLA Class II molecules in humans with leprosy

H. Ohyama; S. Matsushita; K. Hatano; N. Kato; F. Nishimura; S. Takashiba; Y. Murayama

IL-12 production from monocytes induced by stimulus via HLA Class II molecules in humans with leprosy

H. Ohyama, S. Matsushita, K. Hatano, N. Kato, F. Nishimura, S. Takashiba, Y. Murayama

Research output: Contribution to journal › Article › peer-review

Abstract

The objective of this study was to assess whether the difference in cellular immune responses against Mycobacterium leprae among clinical forms would be controlled by the balance between IL-12 from monocytes produced by stimulus via HLA class II molecules and IFN-γ from Th cells in humans with leprosy. Th cell lines reactive with M. leprae major membrane (MMP II) protein were used in this study. The results of this study were as follows: a) IL-12/IL-1β ratio of LL patients tended to be higher than that of TT patients, b) IFN-γ/IL-12 ratio of LL patients was significantly lower than that of TT patients. These results suggest that the clinical forms of leprosy are restricted by the IFN-γ/IL-12 ratio in humans with leprosy.

Original language	English
Number of pages	1
Journal	International Journal of Leprosy and Other Mycobacterial Diseases
Volume	67
Issue number	4 SUPPL.
Publication status	Published - Dec 1 1999
Externally published	Yes

ASJC Scopus subject areas

Dermatology

Cite this

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title = "IL-12 production from monocytes induced by stimulus via HLA Class II molecules in humans with leprosy",

abstract = "The objective of this study was to assess whether the difference in cellular immune responses against Mycobacterium leprae among clinical forms would be controlled by the balance between IL-12 from monocytes produced by stimulus via HLA class II molecules and IFN-γ from Th cells in humans with leprosy. Th cell lines reactive with M. leprae major membrane (MMP II) protein were used in this study. The results of this study were as follows: a) IL-12/IL-1β ratio of LL patients tended to be higher than that of TT patients, b) IFN-γ/IL-12 ratio of LL patients was significantly lower than that of TT patients. These results suggest that the clinical forms of leprosy are restricted by the IFN-γ/IL-12 ratio in humans with leprosy.",

author = "H. Ohyama and S. Matsushita and K. Hatano and N. Kato and F. Nishimura and S. Takashiba and Y. Murayama",

year = "1999",

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T1 - IL-12 production from monocytes induced by stimulus via HLA Class II molecules in humans with leprosy

AU - Ohyama, H.

AU - Matsushita, S.

AU - Hatano, K.

AU - Kato, N.

AU - Nishimura, F.

AU - Takashiba, S.

AU - Murayama, Y.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - The objective of this study was to assess whether the difference in cellular immune responses against Mycobacterium leprae among clinical forms would be controlled by the balance between IL-12 from monocytes produced by stimulus via HLA class II molecules and IFN-γ from Th cells in humans with leprosy. Th cell lines reactive with M. leprae major membrane (MMP II) protein were used in this study. The results of this study were as follows: a) IL-12/IL-1β ratio of LL patients tended to be higher than that of TT patients, b) IFN-γ/IL-12 ratio of LL patients was significantly lower than that of TT patients. These results suggest that the clinical forms of leprosy are restricted by the IFN-γ/IL-12 ratio in humans with leprosy.

AB - The objective of this study was to assess whether the difference in cellular immune responses against Mycobacterium leprae among clinical forms would be controlled by the balance between IL-12 from monocytes produced by stimulus via HLA class II molecules and IFN-γ from Th cells in humans with leprosy. Th cell lines reactive with M. leprae major membrane (MMP II) protein were used in this study. The results of this study were as follows: a) IL-12/IL-1β ratio of LL patients tended to be higher than that of TT patients, b) IFN-γ/IL-12 ratio of LL patients was significantly lower than that of TT patients. These results suggest that the clinical forms of leprosy are restricted by the IFN-γ/IL-12 ratio in humans with leprosy.

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IL-12 production from monocytes induced by stimulus via HLA Class II molecules in humans with leprosy

Abstract

ASJC Scopus subject areas

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