Imipramine-induced c-fos expression in the medial prefrontal cortex is decreased in the ACTH-treated rats

Bingjin Li, Katsuya Suemaru, Yoshihisa Kitamura, Yutaka Gomita, Hiroaki Araki, Ranji Cui

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Previous studies have shown that the antidepressive-like effect of tricyclic antidepressants is blocked by repeated treatments with adrenocorticotropic hormone (ACTH). However, little is known about the neuroanatomy underlying the mechanism of the imipramine treatment-resistant depression model. In the present study, first experimental evidence showed no significant difference of the serum imipramine concentrations between the saline and ACTH-treated rats. In further study, imipramine produced significant increases in the c-Fos expression in the medial prefrontal cortex (mPFC), the dentate gyrus of the hippocampus (DGH), and the central nucleus of the amygdala (CeA), in rats repeatedly treated with saline. The imipramine-increased c-Fos immunoreactivity was suppressed in the mPFC of rats repeatedly treated with ACTH. However, there was no significant difference in c-Fos expression in the DGH and CeA between ACTH- and saline-treated rats. These results suggest that the mPFC is maybe involved in effects of the imipramine in the ACTH-treated rats.

Original languageEnglish
Pages (from-to)486-491
Number of pages6
JournalJournal of Biochemical and Molecular Toxicology
Issue number11
Publication statusPublished - Nov 2013
Externally publishedYes


  • Cell, c-Fos
  • Depression
  • Medial Prefrontal cCrtex

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Toxicology
  • Health, Toxicology and Mutagenesis


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