@article{e5eb5adc1a8b4e7c97f7d6ce005c6de0,
title = "Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody",
abstract = "Kanaya and colleagues show that telomerase-specific oncolytic adenoviruses can facilitate cytotoxic T lymphocytes recruitment into tumor tissues through immunogenic cell death induction, leading to abscopal effects via activation of systemic antitumor immune responses, and combination therapy with anti-PD-1 antibody creates synergistic antitumor effects that even lead to tumor eradication.",
keywords = "CD8, abscopal effect, combined immunotherapy, immune checkpoint, immunogenic cell death, oncolytic adenovirus, programmed death-1, tumor infiltrating lymphocytes",
author = "Nobuhiko Kanaya and Shinji Kuroda and Yoshihiko Kakiuchi and Kento Kumon and Tomoko Tsumura and Masashi Hashimoto and Toshiaki Morihiro and Tetsushi Kubota and Katsuyuki Aoyama and Satoru Kikuchi and Masahiko Nishizaki and Shunsuke Kagawa and Hiroshi Tazawa and Hiroyuki Mizuguchi and Yasuo Urata and Toshiyoshi Fujiwara",
note = "Funding Information: The authors would like to thank Tomoko Sueishi and Tae Yamanishi for their excellent technical support. This work was supported by AMED (grant no. JP17lk0201023 to T.F.) and JSPS KAKENHI (grant no. JP16K19893 to S. Kuroda). Publisher Copyright: {\textcopyright} 2020 The American Society of Gene and Cell Therapy",
year = "2020",
month = mar,
day = "4",
doi = "10.1016/j.ymthe.2020.01.003",
language = "English",
volume = "28",
pages = "794--804",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Nature Publishing Group",
number = "3",
}