Immunohistochemical analysis of intercellular adhesion molecule-1 expression in human gastric adenoma and adenocarcinoma

Ryusuke Nasu, Motowo Mizuno, Takahiko Kiso, Kimihiro Shimo, Tokurou Uesu, Junichirou Nasu, Jun Tomoda, Hiroyuki Okada, Takao Tsuji

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


In this study, we examined the distribution of intercellular adhesion molecule-1 (ICAM-1) in gastric adenomas and carcinomas immunohistochemically at the light and electron microscopic levels. ICAM-1 was expressed on tumour cells in 12 of 28 gastric carcinomas and in 3 of 11 adenomas but not on most normal gastric epithelial cells. ICAM-1 was localized on luminal sites of neoplastic glands in adenomas and in intestinal-type carcinomas, and rarely on the surface of tumour cells of diffuse carcinomas. Expression of ICAM-1 on the tumour cells was more frequent in intestinal-type than diffuse carcinomas (P < 0.005). At the ultrastructural level, ICAM-1 was present prominently on the apical membrane and weakly on the lateral surface of the tumour cells of the intestinal-type carcinoma and also localized on the perinuclear membrane and the membrane of the endoplasmic reticulum of cancer cells. There was no significant association between ICAM-1 expression and HLA antigen expression or the number of infiltrating lymphocyte subsets. These results may implicate the synthesis of ICAM-1 by gastric cancer cells, but the expression is infrequent and may not be sufficient for host immune surveillance of the tumour cell.

Original languageEnglish
Pages (from-to)279-283
Number of pages5
JournalVirchows Archiv
Issue number4
Publication statusPublished - 1997
Externally publishedYes


  • Gastric cancer
  • HLA antigen
  • Immunoelectron microscopy
  • Immunohistochemistry
  • Intercellular adhesion molecule-1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology


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