Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma

Keisuke Nakano; Takehiro Watanabe; Takako Shimizu; Toshiyuki Kawakami

doi:10.7150/ijms.4.264

Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma

Keisuke Nakano, Takehiro Watanabe, Takako Shimizu, Toshiyuki Kawakami

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

Original language	English
Pages (from-to)	264-266
Number of pages	3
Journal	International journal of medical sciences
Volume	4
Issue number	5
DOIs	https://doi.org/10.7150/ijms.4.264
Publication status	Published - Oct 16 2007
Externally published	Yes

Keywords

Bone forming cells
Immunohistochemical characteristics
Modified myoepithelial cell
Pleomorphic adenoma
Trans-differentiation

ASJC Scopus subject areas

Medicine(all)

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10.7150/ijms.4.264

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title = "Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma",

abstract = "Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.",

keywords = "Bone forming cells, Immunohistochemical characteristics, Modified myoepithelial cell, Pleomorphic adenoma, Trans-differentiation",

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T1 - Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma

AU - Nakano, Keisuke

AU - Watanabe, Takehiro

AU - Shimizu, Takako

AU - Kawakami, Toshiyuki

PY - 2007/10/16

Y1 - 2007/10/16

N2 - Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

AB - Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man. Examination results showed the modified neoplastic myoepithelial cells reacted positively to S-100 protein. The S-100-positive modified neoplastic myoepithelial cells were proliferated in the closely related area of the bone tissue. Furthermore, positive reaction was detected in the bone forming cells: osteoblasts and osteocytes. These cells also reacted positively to Runx2 as a marker of bone forming cells. These results suggest that the origin of the bone forming cells in this case of pleomorphic adenoma was modified neoplastic myoepithelial cells.

KW - Bone forming cells

KW - Immunohistochemical characteristics

KW - Modified myoepithelial cell

KW - Pleomorphic adenoma

KW - Trans-differentiation

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Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma

Abstract

Keywords

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