TY - JOUR
T1 - Immunohistochemical localization of connective tissue growth factor in the rat central nervous system
AU - Kondo, Yoichi
AU - Nakanishi, Tohru
AU - Takigawa, Masaharu
AU - Ogawa, Norio
N1 - Funding Information:
This study was supported in part by grants-in-aid for Scientific Research on Priority Area and Scientific Research from the Japanese Ministry of Education, Science, Sports and Culture, grants from Comprehensive Research on Aging and Health and Research on Brain Science from the Japanese Ministry of Health and Welfare.
PY - 1999/7/10
Y1 - 1999/7/10
N2 - Connective tissue growth factor (CTGF) is an immediate early growth- responsive gene but its distribution and significance in the central nervous system (CNS) are unknown. We investigated the distribution of CTGF-like immunoreactivity (CTGF-IR) in the rat CNS using a specific antiserum against CTGF oligopeptide. The majority of CTGF-IR was observed in astrocytes. Ependymal cells lining the wall of the cerebral ventricle and tanycytes lining the central canal of the spinal cord showed the strongest CTGF-IR, while there was a diffuse but weak signal in the gray matter of the spinal cord. CTGF-IR was also detected in the cytoplasm of a subpopulation of pyramidal neurons in the cerebral cortex. Our results showed that CTGF-IR is widely distributed in the CNS at both regional and cellular levels, suggesting a complex functional role in the CNS.
AB - Connective tissue growth factor (CTGF) is an immediate early growth- responsive gene but its distribution and significance in the central nervous system (CNS) are unknown. We investigated the distribution of CTGF-like immunoreactivity (CTGF-IR) in the rat CNS using a specific antiserum against CTGF oligopeptide. The majority of CTGF-IR was observed in astrocytes. Ependymal cells lining the wall of the cerebral ventricle and tanycytes lining the central canal of the spinal cord showed the strongest CTGF-IR, while there was a diffuse but weak signal in the gray matter of the spinal cord. CTGF-IR was also detected in the cytoplasm of a subpopulation of pyramidal neurons in the cerebral cortex. Our results showed that CTGF-IR is widely distributed in the CNS at both regional and cellular levels, suggesting a complex functional role in the CNS.
KW - Astrocyte
KW - Brain
KW - Connective tissue growth factor
KW - Immunohistochemistry
KW - Spinal cord
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U2 - 10.1016/S0006-8993(99)01517-6
DO - 10.1016/S0006-8993(99)01517-6
M3 - Article
C2 - 10407104
AN - SCOPUS:0033542768
SN - 0006-8993
VL - 834
SP - 146
EP - 151
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -