Immunohistochemical localization of connective tissue growth factor in the rat central nervous system

Yoichi Kondo, Tohru Nakanishi, Masaharu Takigawa, Norio Ogawa

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Connective tissue growth factor (CTGF) is an immediate early growth- responsive gene but its distribution and significance in the central nervous system (CNS) are unknown. We investigated the distribution of CTGF-like immunoreactivity (CTGF-IR) in the rat CNS using a specific antiserum against CTGF oligopeptide. The majority of CTGF-IR was observed in astrocytes. Ependymal cells lining the wall of the cerebral ventricle and tanycytes lining the central canal of the spinal cord showed the strongest CTGF-IR, while there was a diffuse but weak signal in the gray matter of the spinal cord. CTGF-IR was also detected in the cytoplasm of a subpopulation of pyramidal neurons in the cerebral cortex. Our results showed that CTGF-IR is widely distributed in the CNS at both regional and cellular levels, suggesting a complex functional role in the CNS.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalBrain Research
Issue number1-2
Publication statusPublished - Jul 10 1999


  • Astrocyte
  • Brain
  • Connective tissue growth factor
  • Immunohistochemistry
  • Spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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