TY - JOUR
T1 - Immunohistochemical localization of macrophage migration inhibitory factor (MIF) in tanycytes, subcommissural organ and choroid plexus in the rat brain
AU - Nishibori, Masahiro
AU - Nakaya, Naoki
AU - Mori, Shuji
AU - Saeki, Kiyomi
N1 - Funding Information:
We ~rat~f~lly acknowledgeS hizuko Yokoyama for her excellent technical assistanceT. his work was partly sup- ported by Grant-in-Aid No. 0667Qll4 from the Japanese Ministry of Education,S cience,Sports and Culture, Japan and a Grant from the Ryobiteien Memorial Foundation.
PY - 1997/5/30
Y1 - 1997/5/30
N2 - We investigated the immunohistochemical localization of the macrophage migration inhibitory factor (MIF) in the rat brain. In addition to epithelial ependymal cells lining the ventricular wall, tanycytes in the basomedial hypothalamus were heavily immunostained. The immunoreactive processes of tanycytes made contacts to sinusoidal capillaries and reached the pial surface forming an immuno-positive structure at the floor of the hypothalamus. Other immunoreactive cells contained the subcommissural organ in the roof of the third ventricle and the epithelial lamina of the choroid plexus. The localization of MIF in cells which have contact with cerebrospinal fluid and blood vessels suggests that MIF might play a role as a humoral factor in the brain.
AB - We investigated the immunohistochemical localization of the macrophage migration inhibitory factor (MIF) in the rat brain. In addition to epithelial ependymal cells lining the ventricular wall, tanycytes in the basomedial hypothalamus were heavily immunostained. The immunoreactive processes of tanycytes made contacts to sinusoidal capillaries and reached the pial surface forming an immuno-positive structure at the floor of the hypothalamus. Other immunoreactive cells contained the subcommissural organ in the roof of the third ventricle and the epithelial lamina of the choroid plexus. The localization of MIF in cells which have contact with cerebrospinal fluid and blood vessels suggests that MIF might play a role as a humoral factor in the brain.
KW - Choroid plexus
KW - Ependyma
KW - Macrophage migration inhibitory factor
KW - Subcommissural organ
KW - Tanycyte
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U2 - 10.1016/S0006-8993(97)00342-9
DO - 10.1016/S0006-8993(97)00342-9
M3 - Article
C2 - 9203559
AN - SCOPUS:0030859207
SN - 0006-8993
VL - 758
SP - 259
EP - 262
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 1-2
ER -