Immunohistochemical observation of BMP in the mouse orthodontic periodontal tension sides

Hirokazu Matsuda, Rina Muraoka, Maki Tomoda, Keisuke Nakano, Norimasa Okafuji, Kazuhiro Yamada, Toshiyuki Kawakami

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


The purpose of this examination was to in vestigate the expression of BMP-2 and -4 in mouse orthodontic periodontal tension sides exposed orthodontic mechanical stress using the method of Waldo. Immnohistochemically, in the experimental group, strong expression of BMP-2 and -4 were observed in the periodontal tension sides at 20minutes. The results strongly suggested that the BMP-2 and -4 promoted the Runx2 expression for osteoblastic differention in the orthodontic periodontal tension sides at the early stage after receiving of the mechanical stress.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalJournal of Hard Tissue Biology
Issue number4
Publication statusPublished - Mar 23 2010
Externally publishedYes


  • BMP
  • Immunohistochemhistory
  • Mechanical stress
  • Orthodontic force
  • Periodontal ligament

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biomaterials
  • Orthopedics and Sports Medicine
  • Dentistry(all)
  • Cell Biology


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