Immunomodulatory and regenerative effects of mesenchymal stem cell-derived extracellular vesicles in renal diseases

Kenji Tsuji, Shinji Kitamura, Jun Wada

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)


Mesenchymal stem cells (MSCs) have immunomodulatory and regenerative effects in many organs, including the kidney. Emerging evidence has shown that the trophic effects from MSCs are mainly mediated by the paracrine mechanism rather than the direct differentiation of MSCs into injured tissues. These secretomes from MSCs include cytokines, growth factors, chemokines and extracellular vesicles (EVs) containing microRNAs, mRNAs, and proteins. Many research studies have revealed that secretomes from MSCs have potential to ameliorate renal injury in renal disease models, including acute kidney injury and chronic kidney disease through a variety of mechanisms. These trophic mechanisms include immunomodulatory and regenerative effects. In addition, accumulating evidence has uncovered the specific factors and therapeutic mechanisms in MSC-derived EVs. In this article, we summarize the recent advances of immunomodulatory and regenerative effects of EVs from MSCs, especially focusing on the microRNAs.

Original languageEnglish
Article number756
JournalInternational journal of molecular sciences
Issue number3
Publication statusPublished - Feb 1 2020


  • Acute kidney injury
  • Chronic kidney disease
  • Extracellular vesicles
  • Immunomodulation
  • Mesenchymal stem cell
  • Renal regeneration
  • microRNA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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