Immunosuppressant FK506 prevents messy fiber sprouting induced by kindling stimulation

Akiyoshi Moriwaki, Yun Fei Lu, Yasushi Hayashi, Kazuhito Tomizawa, Masaaki Tokuda, Toshifumi Itano, Osamu Hatase, Hideki Matsui

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Kindling stimulation induces expansive growth of the axons of the dentate granule cells, the mossy fiber, into several areas of the hippocampus. An intraperitoneal injection of the immunosuppressant drug FK506, which is a specific inhibitor of Ca2+-calmodulin dependent phosphatase, calcineurin, prevented the full development of kindling as well as mossy fiber sprouting. The results show a correlation between mossy fiber sprouting and the development of kindling. The results suggest also that calcineurin may have a promoting role in mossy fiber sprouting and subsequent synaptogenesis.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalNeuroscience Research
Issue number2
Publication statusPublished - Jun 1996


  • Calcineurin
  • FK506
  • Kindling
  • Mossy fiber
  • Phosphatase
  • Sprouting
  • Timm histochemistry

ASJC Scopus subject areas

  • General Neuroscience


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