Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Lizomar J.M.P. Moia; Hideki Matsui; Guilherme A.M. de Barros; Kazuhito Tomizawa; Kazuhiro Miyamoto; Yoshihiro Kuwata; Masaaki Tokuda; Toshifumi Itano; Osamu Hatase

doi:10.1016/0006-8993(94)91138-X

Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Lizomar J.M.P. Moia, Hideki Matsui, Guilherme A.M. de Barros, Kazuhito Tomizawa, Kazuhiro Miyamoto, Yoshihiro Kuwata, Masaaki Tokuda, Toshifumi Itano, Osamu Hatase

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

Original language	English
Pages (from-to)	337-341
Number of pages	5
Journal	Brain Research
Volume	648
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)91138-X
Publication status	Published - Jun 20 1994

Keywords

Calcineurin
Cyclosporin A
FK506
Hippocampus
Immunosuppressant
Kindling
Neocortex
Rat brain

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)91138-X

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@article{4f2ba231f5bc4e09840bb013cf566fd9,

title = "Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat",

abstract = "Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.",

keywords = "Calcineurin, Cyclosporin A, FK506, Hippocampus, Immunosuppressant, Kindling, Neocortex, Rat brain",

author = "Moia, {Lizomar J.M.P.} and Hideki Matsui and {de Barros}, {Guilherme A.M.} and Kazuhito Tomizawa and Kazuhiro Miyamoto and Yoshihiro Kuwata and Masaaki Tokuda and Toshifumi Itano and Osamu Hatase",

note = "Funding Information: We would like to express our special thanks to Dr. T.H. Murakami in the Department of Biology and Dr. T. Negi in the Department of Sports Medicine in The Kagawa Medical School for their technical instruction and support to prepare kindling rats. We also thank to Dr. Najma Janjua for the review of the English of this manuscript. This work was supported by a Grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.",

year = "1994",

month = jun,

day = "20",

doi = "10.1016/0006-8993(94)91138-X",

language = "English",

volume = "648",

pages = "337--341",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "2",

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TY - JOUR

T1 - Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

AU - Moia, Lizomar J.M.P.

AU - Matsui, Hideki

AU - de Barros, Guilherme A.M.

AU - Tomizawa, Kazuhito

AU - Miyamoto, Kazuhiro

AU - Kuwata, Yoshihiro

AU - Tokuda, Masaaki

AU - Itano, Toshifumi

AU - Hatase, Osamu

N1 - Funding Information: We would like to express our special thanks to Dr. T.H. Murakami in the Department of Biology and Dr. T. Negi in the Department of Sports Medicine in The Kagawa Medical School for their technical instruction and support to prepare kindling rats. We also thank to Dr. Najma Janjua for the review of the English of this manuscript. This work was supported by a Grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.

PY - 1994/6/20

Y1 - 1994/6/20

N2 - Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

AB - Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

KW - Calcineurin

KW - Cyclosporin A

KW - FK506

KW - Hippocampus

KW - Immunosuppressant

KW - Kindling

KW - Neocortex

KW - Rat brain

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DO - 10.1016/0006-8993(94)91138-X

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C2 - 7522929

AN - SCOPUS:0028200736

SN - 0006-8993

VL - 648

SP - 337

EP - 341

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Abstract

Keywords

ASJC Scopus subject areas

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