Mesenchymal stem cells (MSCs) have been isolated from bone marrow and various organs and tissues. Nowadays, a large number of tissue regeneration studies using MSCs have been reported because of their multiple differentiation ability. Furthermore, systemic MSC transplantation has been gradually considered as a promising approach for intractable diseases such as autoimmune disease, because of their immunomodulation properties. These remarkable functions are not limited to MSCs from bone marrow or adipose tissue, but also from dental tissues including dental pulp, periodontal ligament, and gingiva. This review first overviews the accumulated evidence about the immunomodulation properties of MSCs, with a focus on dental tissue derived-MSC and their potential application for immunotherapy in dentistry.

Original languageEnglish
Title of host publicationStem Cell Biology and Tissue Engineering in Dental Sciences
PublisherElsevier Inc.
Number of pages9
ISBN (Electronic)9780123977786
ISBN (Print)9780123971579
Publication statusPublished - 2015


  • Dental pulp stem cells
  • Gingival mesenchymal stem cells
  • Immunomodulation
  • Mesenchymal stem cells
  • Periodontal ligament stem cells
  • Regulatory T-cells
  • T-helper type 17 cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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