Impact of age on epidermal growth factor receptor mutation in lung cancer

Tsuyoshi Ueno, Shinichi Toyooka, Kenichi Suda, Junichi Sou, Yasushi Yatabe, Shinichiro Miyoshi, Keitaro Matsuo, Tetsuya Mitsudomi

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Aging is one of the best, but rarely referred, risk factors for various types of cancer including lung cancer, because age could be a surrogate for accumulation of genetic events in cancers. Smoking inversely associates with the presence of epidermal growth factor receptor (EGFR) mutation in lung cancer, but its strong confounding with age and sex makes it difficult to evaluate sole impact of age. To clarify an impact of age on EGFR mutation, we conducted a cross-sectional study based on data of 1262 lung cancer patients. The associations between EGFR mutation and age, considering sex, smoking and histology, were evaluated using logistic regression models. In multivariate analysis, we found a significant increase of EGFR mutation prevalence by increase of age (p-trend = 0.0004). Consistent trend was observed among never-smoking females (p-trend = 0.011) and never-smoking males also showed similar trend although not significant. These were consistently observed when we limit the subject to those with adenocarcinoma. In conclusion, age independently associates with EGFR mutation among lung cancer. Positive association between EGFR mutation and age among never-smokers regardless of sex might indicate that EGFR mutation occurs cumulatively by unidentified internal/external factors other than smoking.

Original languageEnglish
Pages (from-to)207-211
Number of pages5
JournalLung Cancer
Issue number3
Publication statusPublished - Dec 2012


  • Adenocarcinoma
  • Age
  • EGFR
  • Lung cancer
  • Sex
  • Smoking

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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