Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction

Hiroya Mizuno; Hiroshi Sato; Yasuhiko Sakata; Yozo Ohnishi; Eiji Hishida; Kunihiro Kinjo; Daisaku Nakatani; Masahiko Shimizu; Hiroya Kondo; Toshihiro Tanaka; Kouichi Ozaki; Atsushi Hirayama; Hiroshi Ito; Kinya Otsu; Masatsugu Hori

doi:10.1016/j.atherosclerosis.2005.06.020

Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction

Hiroya Mizuno, Hiroshi Sato, Yasuhiko Sakata, Yozo Ohnishi, Eiji Hishida, Kunihiro Kinjo, Daisaku Nakatani, Masahiko Shimizu, Hiroya Kondo, Toshihiro Tanaka, Kouichi Ozaki, Atsushi Hirayama, Hiroshi Ito, Kinya Otsu, Masatsugu Hori

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis- related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.

Original language	English
Pages (from-to)	400-405
Number of pages	6
Journal	Atherosclerosis
Volume	185
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2005.06.020
Publication status	Published - Apr 2006
Externally published	Yes

Keywords

Lymphotoxin alpha
Myocardial infarction
Polymorphism
Prognosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.atherosclerosis.2005.06.020

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Mizuno, H., Sato, H., Sakata, Y., Ohnishi, Y., Hishida, E., Kinjo, K., Nakatani, D., Shimizu, M., Kondo, H., Tanaka, T., Ozaki, K., Hirayama, A., Ito, H., Otsu, K., & Hori, M. (2006). Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction. Atherosclerosis, 185(2), 400-405. https://doi.org/10.1016/j.atherosclerosis.2005.06.020

Mizuno, H, Sato, H, Sakata, Y, Ohnishi, Y, Hishida, E, Kinjo, K, Nakatani, D, Shimizu, M, Kondo, H, Tanaka, T, Ozaki, K, Hirayama, A, Ito, H, Otsu, K & Hori, M 2006, 'Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction', Atherosclerosis, vol. 185, no. 2, pp. 400-405. https://doi.org/10.1016/j.atherosclerosis.2005.06.020

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title = "Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction",

abstract = "Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis- related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.",

keywords = "Lymphotoxin alpha, Myocardial infarction, Polymorphism, Prognosis",

author = "Hiroya Mizuno and Hiroshi Sato and Yasuhiko Sakata and Yozo Ohnishi and Eiji Hishida and Kunihiro Kinjo and Daisaku Nakatani and Masahiko Shimizu and Hiroya Kondo and Toshihiro Tanaka and Kouichi Ozaki and Atsushi Hirayama and Hiroshi Ito and Kinya Otsu and Masatsugu Hori",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for University and Society Collaboration (#15590743) from the Japanese Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan and by a research grant from Japan Arteriosclerosis Prevention Fund. ",

year = "2006",

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doi = "10.1016/j.atherosclerosis.2005.06.020",

language = "English",

volume = "185",

pages = "400--405",

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T1 - Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction

AU - Mizuno, Hiroya

AU - Sato, Hiroshi

AU - Sakata, Yasuhiko

AU - Ohnishi, Yozo

AU - Hishida, Eiji

AU - Kinjo, Kunihiro

AU - Nakatani, Daisaku

AU - Shimizu, Masahiko

AU - Kondo, Hiroya

AU - Tanaka, Toshihiro

AU - Ozaki, Kouichi

AU - Hirayama, Atsushi

AU - Ito, Hiroshi

AU - Otsu, Kinya

AU - Hori, Masatsugu

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for University and Society Collaboration (#15590743) from the Japanese Ministry of Education, Culture, Sports, Science and Technology, Tokyo, Japan and by a research grant from Japan Arteriosclerosis Prevention Fund.

PY - 2006/4

Y1 - 2006/4

N2 - Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis- related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.

AB - Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis- related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.

KW - Lymphotoxin alpha

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KW - Prognosis

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Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction

Abstract

Keywords

ASJC Scopus subject areas

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