TY - JOUR
T1 - Impact of electrosurgical unit mode on post esophageal endoscopic submucosal dissection stricture in an in vivo porcine model
AU - Tonai, Yusuke
AU - Ishihara, Ryu
AU - Yamasaki, Yasushi
AU - Arao, Masamichi
AU - Iwatsubo, Taro
AU - Kato, Minoru
AU - Suzuki, Syo
AU - Hamada, Kenta
AU - Shichijo, Satoki
AU - Matsuura, Noriko
AU - Kanesaka, Takashi
AU - Nakahira, Hiroko
AU - Yamamoto, Sachiko
AU - Akasaka, Tomofumi
AU - Hanaoka, Noboru
AU - Takeuchi, Yoji
AU - Higashino, Koji
AU - Uedo, Noriya
AU - Tomita, Yasuhiko
AU - Iishi, Hiroyasu
PY - 2018/3
Y1 - 2018/3
N2 - Background and aim: Strictures are a major complication of esophageal endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma. Post ESD, stricture develops during the process of scar formation, which is related to inflammation caused by ESD. We planned a study to evaluate whether certain electrosurgical unit modes could attenuate strictures after esophageal ESD.Methods: A total of 16 ESD, three-quarters of the esophageal circumference, were performed in four live pigs. A ball-tip Flush knife was used for mucosal incision. Submucosal dissection was performed using a Hook knife in monopolar mode and a ball-tip Jet B-knife in bipolar mode. Applied electrosurgical unit modes were FORCED COAG, SWIFT COAG, SPRAY COAG, ENDO CUT in monopolar mode, and FORCED COAG in bipolar mode. One month after ESD, the pigs were killed humanely and the severity of strictures and fibrosis was assessed.Results: The resected site in the esophagus showed complete mucosal regrowth and scar formation in all pigs. The quotients of stricture following ENDO CUT, SWIFT COAG, FORCED COAG effect2, FORCED COAG effect3, FORCED COAG effect4, SPRAY COAG, and Bipolar FORCED COAG mode were 16 %, 28 %, 38 %, 33 %, 51 %, 39 %, and 47 %, respectively. The equivalent quotients of fibrosis were 7 %, 28 %, 31 %, 30 %, 35 %, 63 %, and 100 %, respectively. ENDO CUT mode was associated with the lowest mean quotients of stricture and fibrosis.Conclusion: ENDO CUT mode showed promising results to attenuate fibrosis and strictures after esophageal ESD.
AB - Background and aim: Strictures are a major complication of esophageal endoscopic submucosal dissection (ESD) for superficial esophageal carcinoma. Post ESD, stricture develops during the process of scar formation, which is related to inflammation caused by ESD. We planned a study to evaluate whether certain electrosurgical unit modes could attenuate strictures after esophageal ESD.Methods: A total of 16 ESD, three-quarters of the esophageal circumference, were performed in four live pigs. A ball-tip Flush knife was used for mucosal incision. Submucosal dissection was performed using a Hook knife in monopolar mode and a ball-tip Jet B-knife in bipolar mode. Applied electrosurgical unit modes were FORCED COAG, SWIFT COAG, SPRAY COAG, ENDO CUT in monopolar mode, and FORCED COAG in bipolar mode. One month after ESD, the pigs were killed humanely and the severity of strictures and fibrosis was assessed.Results: The resected site in the esophagus showed complete mucosal regrowth and scar formation in all pigs. The quotients of stricture following ENDO CUT, SWIFT COAG, FORCED COAG effect2, FORCED COAG effect3, FORCED COAG effect4, SPRAY COAG, and Bipolar FORCED COAG mode were 16 %, 28 %, 38 %, 33 %, 51 %, 39 %, and 47 %, respectively. The equivalent quotients of fibrosis were 7 %, 28 %, 31 %, 30 %, 35 %, 63 %, and 100 %, respectively. ENDO CUT mode was associated with the lowest mean quotients of stricture and fibrosis.Conclusion: ENDO CUT mode showed promising results to attenuate fibrosis and strictures after esophageal ESD.
U2 - 10.1055/s-0043-122883
DO - 10.1055/s-0043-122883
M3 - Article
C2 - 29527561
SN - 2364-3722
VL - 6
SP - E376-E381
JO - Endoscopy International Open
JF - Endoscopy International Open
IS - 3
ER -