Improved Bone Mineral Status in Very Low Birthweight Infants Fed Human Milk Mixed with Preterm Formula

Hirokazu Tsukahara, Izuru Mitsuyoshi, Tadahiko Sakaguchi, Hitoo Fukuhara, Shuhei Hayashi, Katsuji Nakamura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


The bone mineral status of very low birthweight (VLBW) infants fed exclusively their own mother's milk (group I) was compared with that of VLBW infants fed mother's milk in the initial 4 weeks followed by a 1:1 mixture of mother's milk and preterm formula containing high phosphorus (P) and calcium (Ca) (group II). In both groups, most infants showed a biochemical picture characteristic of phosphorus deficiency syndrome by the fourth week. Thereafter, serum alkaline phosphatase activity (ALP) decreased and serum P increased in all group II infants. Conversely, serum ALP rose and hypophosphatemia persisted in most group I infants. Group II had a significantly higher serum P at weeks 8 and 12 and a significantly lower ALP at week 12 than group I. Furthermore, group II had a lower incidence of severe radiographic abnormalities than group I at week 12. We confumed previous observations that VLBW infants fed exclusively human milk require P and Ca supplementation to prevent metabolic bone disease of prematurity.

Original languageEnglish
Pages (from-to)58-64
Number of pages7
JournalPediatrics International
Issue number1
Publication statusPublished - 1989
Externally publishedYes


  • Metabolic bone disease of prematurity
  • Phosphorus and calcium supplementation
  • Phosphorus deficiency syndrome
  • Preterm formula
  • Very low birthweight infant

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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