Improved synthesis and crystal structure of TiCl3(tmeda)(thf): A highly stereoselective pinacol coupling reagent for aromatic aldehydes

Toshiyuki Oshiki; Takayuki Kiriyama; Kazuaki Tsuchida; Kazuhiko Takai

doi:10.1246/cl.2000.334

Improved synthesis and crystal structure of TiCl₃(tmeda)(thf): A highly stereoselective pinacol coupling reagent for aromatic aldehydes

Toshiyuki Oshiki, Takayuki Kiriyama, Kazuaki Tsuchida, Kazuhiko Takai

School of Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

A monomeric titanium(III) complex, TiCl₃(tmeda)(thf) (1), has been prepared by a reaction of TiCl₄ with TMEDA, Zn, and a catalytic amount of PbCl₂ in an almost quantitative yield. The solid state structure of 1 is revealed by X-ray crystallographic analysis. The complex 1 couples aromatic aldehydes under mild conditions to give 1,2-diols in good to excellent yields with high d/-selectivities.

Original language	English
Pages (from-to)	334-335
Number of pages	2
Journal	Chemistry Letters
Issue number	4
DOIs	https://doi.org/10.1246/cl.2000.334
Publication status	Published - Jan 1 2000

ASJC Scopus subject areas

Chemistry(all)

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abstract = "A monomeric titanium(III) complex, TiCl3(tmeda)(thf) (1), has been prepared by a reaction of TiCl4 with TMEDA, Zn, and a catalytic amount of PbCl2 in an almost quantitative yield. The solid state structure of 1 is revealed by X-ray crystallographic analysis. The complex 1 couples aromatic aldehydes under mild conditions to give 1,2-diols in good to excellent yields with high d/-selectivities.",

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doi = "10.1246/cl.2000.334",

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journal = "Chemistry Letters",

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AU - Kiriyama, Takayuki

AU - Tsuchida, Kazuaki

AU - Takai, Kazuhiko

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AB - A monomeric titanium(III) complex, TiCl3(tmeda)(thf) (1), has been prepared by a reaction of TiCl4 with TMEDA, Zn, and a catalytic amount of PbCl2 in an almost quantitative yield. The solid state structure of 1 is revealed by X-ray crystallographic analysis. The complex 1 couples aromatic aldehydes under mild conditions to give 1,2-diols in good to excellent yields with high d/-selectivities.

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Improved synthesis and crystal structure of TiCl₃(tmeda)(thf): A highly stereoselective pinacol coupling reagent for aromatic aldehydes

Abstract

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