In vitro analysis of radioprotective effect of monoterpenes

Ken ichi Kudo, Tadashi Hanafusa, Toshiro Ono

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Monoterpenes are naturally occurring hydrocarbons composed of two units of isoprenes. They exhibit antioxidant activity to scavenge reactive oxygen species, such as hydroxyl radicals. We investigated the potential of monoterpenes such as thymol, linalool, and menthol to act as radioprotectants. The proliferation of EL4 cells, a mouse lymphoma cell line, treated with linalool at a concentration of 500 μM or more was not affected by X-ray irradiation. Plasmid-nicking assay performed using formamidopyrimidine-DNA glycosylase showed that linalool prevented single strand breaks and oxidized purines on pUC19 plasmid DNA. These findings indicate that linalool has the ability to scavenge reactive oxygen species and is a potential radioprotector.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number1
Publication statusPublished - Jul 1 2017


  • Linalool
  • Monoterpenes
  • Reactive oxygen species
  • SSB
  • X-ray irradiation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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