TY - JOUR
T1 - In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum
AU - Begum, Khurshida
AU - Kim, Hye Sook
AU - Kumar, Veena
AU - Stojiljkovic, Igor
AU - Wataya, Yusuke
N1 - Funding Information:
Acknowledgement This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (13226079 and 14021072) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.
AB - The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.
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U2 - 10.1007/s00436-003-0830-9
DO - 10.1007/s00436-003-0830-9
M3 - Article
C2 - 12783311
AN - SCOPUS:0038686310
SN - 0932-0113
VL - 90
SP - 221
EP - 224
JO - Parasitology Research
JF - Parasitology Research
IS - 3
ER -
