In vitro degradation behavior of hydroxyapatite

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)


This chapter discusses in vitro degradation behaviors of calcium phosphate particles, such as nano-crystalline hydroxyapatite (HAp) and ion-substituted HAp synthesized by the wet-chemical processing method, and how their microstructure affects their initial dissolution profiles and kinetics. The chapter reviews several in vitro evaluation techniques for biodegradability of calcium phosphate ceramics and several models representing dissolution profiles and kinetics. The chapter then discusses the relationship between the heterogeneous structure of nano-crystalline HAp and the initial dissolution behaviors in acidic buffer solution.

Original languageEnglish
Title of host publicationHydroxyapatite (HAp) for Biomedical Applications
PublisherElsevier Ltd
Number of pages21
ISBN (Electronic)9781782420415
ISBN (Print)9781782420330
Publication statusPublished - Feb 27 2015


  • Amorphous phase
  • Biodegradation
  • Calcium phosphate
  • Disordered phase
  • Dissolution kinetics
  • Dissolution rate
  • Hydroxyapatite
  • In vitro degradation
  • Ionic substitution
  • Nano-crystal

ASJC Scopus subject areas

  • General Engineering
  • General Materials Science


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