@inbook{85957462d8ce4fdd8df5199f6e259201,
title = "In vivo evaluation of cartilage regenerative effects of CCN2 protein",
abstract = "CCN family protein 2/connective tissue growth factor (CCN2/CTGF) is a unique growth factor that promotes the proliferation and differentiation, but not the hypertrophy of articular chondrocytes in vitro. Based on these fi ndings, we previously evaluated the cartilage-regenerative effects of recombinant CCN2 protein (rCCN2) by using both mono-iodoacetate (MIA) injection into the rat joint cavity and formation of full-thickness defects of rat articular cartilage in vivo, and our results suggested the utility of CCN2 in the regeneration of articular cartilage. This chapter entails helpful tips to apply these two animal models for the evaluation of cartilage-regenerative effects of CCN2 or its derivatives.",
keywords = "Articular cartilage, Collagen sponge, Full-thickness defects, Gelatin hydrogels, Micro drill, Mono-iodoacetic acid (MIA), Recombinant CCN2 protein (rCCN2), Regeneration and repair",
author = "Takashi Nishida and Satoshi Kubota and Masaharu Takigawatakigawa",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2017.",
year = "2017",
doi = "10.1007/978-1-4939-6430-7_25",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "273--282",
booktitle = "Methods in Molecular Biology",
}