In vivo internal diffusion of several inorganic microparticles through oral administration

Shigeaki Abe, Chila Koyama, Mitsue Esaki, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Manabu Morita, Fumio Watari

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


We observed the internal diffusion behavior of inorganic micro/nano particles through oral administration. By oral exposure, the fed particles were absorbed through the digestive system then reached some organs after internal diffusion in the body. For example, TiO2 particles fed to mice were detected in the lung, liver, and spleen after 10 days of feeding. Whereas, the absorption efficiency was extremely low compared with intravenous injection. In a comparison of the simple amount of administration, oral exposure required 102 times or more amount by intravenous injection for detection by an X-ray scanning analytical microscope. During dental treatment, micro/nano particles from tooth or dental materials would generate in the oral cavity, and some of the particles had a possibility to be swallowed, absorbed through the digestive system, and then diffuse into the body. However, our results suggest that biocompatible microparticles that are naturally taken orally affect animals only rarely because of the low absorption efficiency.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
JournalBio-Medical Materials and Engineering
Issue number2-3
Publication statusPublished - 2009


  • Biodistribution
  • Micro-sized particles
  • Nano-sized particles
  • Oral administration

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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