In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat

Yuichiro Minamoto; Toshifumi Itano; Masaaki Tokuda; Hideki Matsui; Najma A. Janjua; Kiyoshi Hosokawa; Yasushi Okada; Tetuhide H. Murakami; Tetsuro Negi; Osamu Hatase

doi:10.1016/0006-8993(92)90786-9

In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat

Yuichiro Minamoto, Toshifumi Itano, Masaaki Tokuda, Hideki Matsui, Najma A. Janjua, Kiyoshi Hosokawa, Yasushi Okada, Tetuhide H. Murakami, Tetsuro Negi, Osamu Hatase

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Extracellular concentrations of γ-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.

Original language	English
Pages (from-to)	345-348
Number of pages	4
Journal	Brain Research
Volume	573
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(92)90786-9
Publication status	Published - Feb 28 1992
Externally published	Yes

Keywords

Aspartate
Epilepsy
Glutamate
Kindling
Microdialysis
γ-Aminobutyric acid

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(92)90786-9

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title = "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat",

abstract = "Extracellular concentrations of γ-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.",

keywords = "Aspartate, Epilepsy, Glutamate, Kindling, Microdialysis, γ-Aminobutyric acid",

author = "Yuichiro Minamoto and Toshifumi Itano and Masaaki Tokuda and Hideki Matsui and Janjua, {Najma A.} and Kiyoshi Hosokawa and Yasushi Okada and Murakami, {Tetuhide H.} and Tetsuro Negi and Osamu Hatase",

note = "Funding Information: and the Grant of Japan Epilepsy Research Foundation, Osaka Japan. Funding Information: This work was supported by Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan,",

year = "1992",

month = feb,

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doi = "10.1016/0006-8993(92)90786-9",

language = "English",

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pages = "345--348",

journal = "Molecular Brain Research",

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T1 - In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat

AU - Minamoto, Yuichiro

AU - Itano, Toshifumi

AU - Tokuda, Masaaki

AU - Matsui, Hideki

AU - Janjua, Najma A.

AU - Hosokawa, Kiyoshi

AU - Okada, Yasushi

AU - Murakami, Tetuhide H.

AU - Negi, Tetsuro

AU - Hatase, Osamu

N1 - Funding Information: and the Grant of Japan Epilepsy Research Foundation, Osaka Japan. Funding Information: This work was supported by Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Science and Culture of Japan,

PY - 1992/2/28

Y1 - 1992/2/28

N2 - Extracellular concentrations of γ-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.

AB - Extracellular concentrations of γ-aminobutyric acid (GABA), glutamate (Glu) and aspartate (Asp) were determined by microdialysis in rat hippocampus during various amygdaloid kindled stages. The values of GABA and Glu were increased 3-4 times in C2-C3 stages in comparison with the values in control animals. After reaching the C5 stage, these values were increased 3-7 times. However, the concentration of Asp decreased depending on the kindling stage, reaching the lowest value of 33% in comparison with the normal value. The observed changes may be related to kindling induced seizures.

KW - Aspartate

KW - Epilepsy

KW - Glutamate

KW - Kindling

KW - Microdialysis

KW - γ-Aminobutyric acid

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JO - Molecular Brain Research

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In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat

Abstract

Keywords

ASJC Scopus subject areas

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