In Vivo Microwave Ablation of Normal Swine Lung at High-power, Short-duration Settings

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To evaluate the volume and heat-sink effects of microwave ablation (MWA) in the ablation zone of the normal swine lung. MWA at 100 W was performed for 1, 2, and 3 min in 7, 5, and 5 lung zones, respectively. We assessed the histopathology in the ablation zones and other outcome measures: namely, length of the longest long and short axes, sphericity, ellipsoid area, and ellipsoid volume. The mean long and short-axis diameters were 22.0 and 14.1 mm in the 1-min ablation zone, 27.6 and 20.2 mm in the 2-min ablation zone; and 29.2 and 21.2 mm in the 3-min ablation zone, respectively. All measures, except sphericity, were significantly less with 1-min ablation than with either 2 or 3-min ablation. There were no significant differences between the 2 and 3-min ablation zones, but all measures except sphericity were larger with 3-min ablation. Although there were no blood vessels that resulted in a heat-sink effect within the ablation zones, the presence of bronchi nearby in 5 lung ablation zones resulted in reduced ablation size. In high-power, short-duration MWA, the lung ablation volume was affected by ablation time. Some ablations showed that a heat-sink effect by a neigh-boring bronchus might occur.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalActa medica Okayama
Issue number1
Publication statusPublished - 2022


  • Ablation zone
  • Heat-sink effect
  • Lung
  • Microwave ablation
  • Swine

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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