TY - JOUR
T1 - Increased expression of cyclooxygenase-2 in human salivary gland tumors
AU - Sakurai, Kazunari
AU - Urade, Masahiro
AU - Noguchi, Kazuma
AU - Kishimoto, Hiromitsu
AU - Ishibashi, Miki
AU - Yasoshima, Hitoshi
AU - Yamamoto, Tadashi
AU - Kubota, Akira
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 2001
Y1 - 2001
N2 - We examined the immunohistochemical localization of cyclooxygenase (COX)-2 in human salivary gland tumors. Thirty salivary gland adenomas (SGA), 40 salivary gland carcinomas (SGC) and 15 normal salivary glands (NSG) were studied. NSG showed restricted COX-2 staining only in the epithelial cells of salivary ducts. In contrast, COX-2 protein was detected in 27 cases of SGA (90%), except for three myoepitheliomas, and in all cases of SGC (100%) at various intensities and in various fashions. Thirteen SGA (43%) and 36 SGC (90%) cases showed strong COX-2 staining predominantly in tumor cells containing ductal components, as did serous and mucous acinic components of acinic cell carcinomas, mucoepidermoid carcinomas and mucinous carcinomas. These findings may suggest that COX-2 in salivary gland tumors is expressed in tumor cells derived from pluripotential ductal epithelium that can histologically develop into either serous or mucinous acinar cells.
AB - We examined the immunohistochemical localization of cyclooxygenase (COX)-2 in human salivary gland tumors. Thirty salivary gland adenomas (SGA), 40 salivary gland carcinomas (SGC) and 15 normal salivary glands (NSG) were studied. NSG showed restricted COX-2 staining only in the epithelial cells of salivary ducts. In contrast, COX-2 protein was detected in 27 cases of SGA (90%), except for three myoepitheliomas, and in all cases of SGC (100%) at various intensities and in various fashions. Thirteen SGA (43%) and 36 SGC (90%) cases showed strong COX-2 staining predominantly in tumor cells containing ductal components, as did serous and mucous acinic components of acinic cell carcinomas, mucoepidermoid carcinomas and mucinous carcinomas. These findings may suggest that COX-2 in salivary gland tumors is expressed in tumor cells derived from pluripotential ductal epithelium that can histologically develop into either serous or mucinous acinar cells.
KW - Cyclooxygenase-2 (COX-2)
KW - Immunohistochemistry
KW - Increased expression
KW - Salivary gland tumors
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U2 - 10.1046/j.1440-1827.2001.01280.x
DO - 10.1046/j.1440-1827.2001.01280.x
M3 - Article
C2 - 11881728
AN - SCOPUS:0035164852
SN - 1320-5463
VL - 51
SP - 762
EP - 769
JO - Pathology International
JF - Pathology International
IS - 10
ER -