Increased expression of cyclooxygenase-2 in human salivary gland tumors

Kazunari Sakurai, Masahiro Urade, Kazuma Noguchi, Hiromitsu Kishimoto, Miki Ishibashi, Hitoshi Yasoshima, Tadashi Yamamoto, Akira Kubota

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


We examined the immunohistochemical localization of cyclooxygenase (COX)-2 in human salivary gland tumors. Thirty salivary gland adenomas (SGA), 40 salivary gland carcinomas (SGC) and 15 normal salivary glands (NSG) were studied. NSG showed restricted COX-2 staining only in the epithelial cells of salivary ducts. In contrast, COX-2 protein was detected in 27 cases of SGA (90%), except for three myoepitheliomas, and in all cases of SGC (100%) at various intensities and in various fashions. Thirteen SGA (43%) and 36 SGC (90%) cases showed strong COX-2 staining predominantly in tumor cells containing ductal components, as did serous and mucous acinic components of acinic cell carcinomas, mucoepidermoid carcinomas and mucinous carcinomas. These findings may suggest that COX-2 in salivary gland tumors is expressed in tumor cells derived from pluripotential ductal epithelium that can histologically develop into either serous or mucinous acinar cells.

Original languageEnglish
Pages (from-to)762-769
Number of pages8
JournalPathology International
Issue number10
Publication statusPublished - 2001
Externally publishedYes


  • Cyclooxygenase-2 (COX-2)
  • Immunohistochemistry
  • Increased expression
  • Salivary gland tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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