Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas

Kimio Yoshizato; Jun Ichi Kuratsu; Hideo Takeshima; Toru Nishi; Teizo Yoshimura; Yukitaka Ushio

Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas

Kimio Yoshizato, Jun Ichi Kuratsu, Hideo Takeshima, Toru Nishi, Teizo Yoshimura, Yukitaka Ushio

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that MCP-1 expression was highly induced by tumor necrosis factor-α (TNFα) and interleukin-1β. The intra-tumoral injection of TNFα in rat glioma model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection and induced macrophage infiltration into tumor tissue. The injection of TNFα into post-operative tumor cavity of human malignant glioma also increased the concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These data, together with the previous finding that the growth of transplanted MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, suggest that injection of TNFα inhibits tumor growth via the induction of MCP-1 expression.

Original language	English
Pages (from-to)	493-497
Number of pages	5
Journal	International journal of oncology
Volume	8
Issue number	3
Publication status	Published - Mar 1 1996
Externally published	Yes

Keywords

Glioma
Macrophage infiltration
Monocyte chemoattractant protein-1
Tumor necrosis factor-α

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas",

abstract = "We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that MCP-1 expression was highly induced by tumor necrosis factor-α (TNFα) and interleukin-1β. The intra-tumoral injection of TNFα in rat glioma model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection and induced macrophage infiltration into tumor tissue. The injection of TNFα into post-operative tumor cavity of human malignant glioma also increased the concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These data, together with the previous finding that the growth of transplanted MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, suggest that injection of TNFα inhibits tumor growth via the induction of MCP-1 expression.",

keywords = "Glioma, Macrophage infiltration, Monocyte chemoattractant protein-1, Tumor necrosis factor-α",

author = "Kimio Yoshizato and Kuratsu, {Jun Ichi} and Hideo Takeshima and Toru Nishi and Teizo Yoshimura and Yukitaka Ushio",

year = "1996",

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language = "English",

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T1 - Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas

AU - Yoshizato, Kimio

AU - Kuratsu, Jun Ichi

AU - Takeshima, Hideo

AU - Nishi, Toru

AU - Yoshimura, Teizo

AU - Ushio, Yukitaka

PY - 1996/3/1

Y1 - 1996/3/1

N2 - We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that MCP-1 expression was highly induced by tumor necrosis factor-α (TNFα) and interleukin-1β. The intra-tumoral injection of TNFα in rat glioma model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection and induced macrophage infiltration into tumor tissue. The injection of TNFα into post-operative tumor cavity of human malignant glioma also increased the concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These data, together with the previous finding that the growth of transplanted MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, suggest that injection of TNFα inhibits tumor growth via the induction of MCP-1 expression.

AB - We compared the in vitro effects of various cytokines on the expression of monocyte chemoattractant protein-1 (MCP-1) in glioma cell lines and found that MCP-1 expression was highly induced by tumor necrosis factor-α (TNFα) and interleukin-1β. The intra-tumoral injection of TNFα in rat glioma model increased the in vivo expression of MCP-1 at 1 to 12 h after the injection and induced macrophage infiltration into tumor tissue. The injection of TNFα into post-operative tumor cavity of human malignant glioma also increased the concentration of MCP-1 in the cavity fluid at 24 to 38 h after injection. These data, together with the previous finding that the growth of transplanted MCP-1-transfected cells was significantly inhibited by infiltrated macrophages, suggest that injection of TNFα inhibits tumor growth via the induction of MCP-1 expression.

KW - Glioma

KW - Macrophage infiltration

KW - Monocyte chemoattractant protein-1

KW - Tumor necrosis factor-α

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Increased monocyte chemoattractant protein-1 expression by tumor necrosis factor-α can mediate macrophage infiltration in gliomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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