Increment of synapsin I immunoreactivity in the hippocampus of the rat kindling model of epilepsy

Shuji Suemaru, Keiko Sato, Kiyoshi Morimoto, Norihito Yamada, Toshiki Sato, Shigetoshi Kuroda

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Synapsin is a vesicle-associated protein that is thought to be involved in synaptogenesis and neurotransmitter release. In this study, we investigated the repeated amygdala kindling-induced changes in levels of synapsin I, a marker of enhanced synaptic activity, using immunohistochemistry. Eight hours after the last seizure, synapsin I immunoreactivity (IR) was increased bilaterally in the polymorphic zone of the dentate gyrus, the hilus and the stratum lucidum in area CA3 of the hippocampus. However, 4 weeks after the last kindled seizures, synapsin I IR was not significantly changed in any of the brain regions studied. Therefore, the increased levels of synapsin I protein observed in these brain regions early after the last seizure may reflect the plastic changes that occur in the specific neural networks of the hippocampus directly after kindling- induced seizure activity. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)1319-1322
Number of pages4
Issue number6
Publication statusPublished - Apr 27 2000


  • Amygdala kindling
  • Hippocampus
  • Immunohistochemistry
  • Synapsin I

ASJC Scopus subject areas

  • General Neuroscience


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