Inducer-specific regulators of tumor necrosis factor alpha production

Hiroyuki Miyachi; Akihiko Azuma; Erika Hioki; Yoshiro Kobayashi; Shigeo Iwasaki; Yuichi Hashimoto

doi:10.1248/cpb.44.1980

Inducer-specific regulators of tumor necrosis factor alpha production

Hiroyuki Miyachi, Akihiko Azuma, Erika Hioki, Yoshiro Kobayashi, Shigeo Iwasaki, Yuichi Hashimoto

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Novel potent regulators of tumor necrosis factor alpha (TNF-α) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-α production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate- induced TNF-α production, while they inhibited okadaic acid-induced one.

Original language	English
Pages (from-to)	1980-1982
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	44
Issue number	10
DOIs	https://doi.org/10.1248/cpb.44.1980
Publication status	Published - Oct 1996

Keywords

HL-60
okadaic acid
phorbol ester
tumor necrosis factor

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.44.1980

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AU - Azuma, Akihiko

AU - Hioki, Erika

AU - Kobayashi, Yoshiro

AU - Iwasaki, Shigeo

AU - Hashimoto, Yuichi

PY - 1996/10

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N2 - Novel potent regulators of tumor necrosis factor alpha (TNF-α) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-α production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate- induced TNF-α production, while they inhibited okadaic acid-induced one.

AB - Novel potent regulators of tumor necrosis factor alpha (TNF-α) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-α production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate- induced TNF-α production, while they inhibited okadaic acid-induced one.

KW - HL-60

KW - okadaic acid

KW - phorbol ester

KW - tumor necrosis factor

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Inducer-specific regulators of tumor necrosis factor alpha production

Abstract

Keywords

ASJC Scopus subject areas

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