Induction chemotherapy followed by adjuvant surgery (IC-AS) in patients with stage I-II small cell lung cancer (SCLC)

T. Shibayama, J. Hiyama, H. Ueoka, M. Tabata, Y. Segawa, K. Gemba, A. Matsushita, T. Ohnoshi, M. Harada, A. Andoh, N. Shimizu, S. Hiraki

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Ten patients with stage I-II SCLC received IC-AS between 1984 and 1993. As induction chemotherapy, COMP-VAN alternating chemotherapy and CAV-PVP hybrid chemotherapy were administered. The former consisted of a 4 drug combination of cyclophosphamide(CPA), vincristine(VCR), methotrexate (MTX) and procarbazine alternated with a 3-drug combination of etoposide (ETP), adriamycin (ADM) and nimustine every 4 weeks. In the latter, a 3 drug combination of CPA, ADM and VCR given on day 1, and a 2 drug combination of ETP and cisplatin on day 8, were repeated every 4 weeks. All the patients had an objective response, including one complete response by induction chemotherapy. Post-operative pathology revealed SCLC in 4 patients, adenocarcinoma in 2 and no tumor (pathological CR) in 4. Four patients relapsed, and a intrathoracic relapse was experienced in only 2 patients. Six patients have died: 3 from relapsing SCLC, 2 from stomach cancer, and 1 from squamous lung cancer, who was salvaged from relapsing SCLC. The median survival time was 27.5 months, and the 3-year survival rate 37.5%. These results indicate that IC-AS is highly effective for stage I-II SCLC and warrant additional studies comparing IC-AS with chemo-radiotherapy.

Original languageEnglish
Pages (from-to)1953-1958
Number of pages6
JournalJapanese Journal of Cancer and Chemotherapy
Issue number13
Publication statusPublished - 1995


  • Chemotherapy
  • Small cell lung cancer
  • Surgery

ASJC Scopus subject areas

  • General Medicine


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