TY - JOUR
T1 - Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)
AU - Takigawa, Masaharu
AU - Nishida, Yukimitsu
AU - Suzuki, Fujio
AU - Kishi, Jun ichi
AU - Yamashita, Kyoko
AU - Hayakawa, Taro
N1 - Funding Information:
was supported in part by Grants-in-Aid Ministry of: Education, Science and Culture from the Kowa Life Science Foundation (M.T.)
Funding Information:
for Scientific Research of Japan (M.T., F.S.), and the Naito Foundation
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1990/9/28
Y1 - 1990/9/28
N2 - Treatment of yolk-sac membranes of 4-day-old chick embryos with spermine or spermidine resulted in angiogenesis in the membranes. The angiogenic activity of spermine was stronger than that of spermidine. Putrescine, polylysine and histamine did not induce angiogenesis in the membranes. Administration of putrescine, spermidine and spermine increased their respective levels in yolk-sac membranes, but no interconversion of these amines was observed. The increases in spermidine and spermine levels in yolk-sac membranes preceded induction of angiogenesis. The angiogenesis induced by spermine was inhibited by tissue inhibitors of metalloproteinases, that is, TIMP and TIMP-2. These findings suggest that spermine and spermidine are angiogenesis factors in yolk-sac membranes of chick embryos and that matrix metalloproteinases represented by collagenase are involved in their action.
AB - Treatment of yolk-sac membranes of 4-day-old chick embryos with spermine or spermidine resulted in angiogenesis in the membranes. The angiogenic activity of spermine was stronger than that of spermidine. Putrescine, polylysine and histamine did not induce angiogenesis in the membranes. Administration of putrescine, spermidine and spermine increased their respective levels in yolk-sac membranes, but no interconversion of these amines was observed. The increases in spermidine and spermine levels in yolk-sac membranes preceded induction of angiogenesis. The angiogenesis induced by spermine was inhibited by tissue inhibitors of metalloproteinases, that is, TIMP and TIMP-2. These findings suggest that spermine and spermidine are angiogenesis factors in yolk-sac membranes of chick embryos and that matrix metalloproteinases represented by collagenase are involved in their action.
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U2 - 10.1016/0006-291X(90)90822-5
DO - 10.1016/0006-291X(90)90822-5
M3 - Article
C2 - 1699524
AN - SCOPUS:0025159845
SN - 0006-291X
VL - 171
SP - 1264
EP - 1271
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -