TY - JOUR
T1 - Induction of spermidine/spermine N-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture
AU - Matsui-yuasa, Isao
AU - Otani, Shuzo
AU - Morisawa, Seiji
AU - Takigawa, Masaharu
AU - Enomoto, Motomi
AU - Suzuki, Fujio
PY - 1985/1
Y1 - 1985/1
N2 - Parathyroid hormone (PTH) increased the activity of spermidine/spermine N1-acetyltransferase, a rate-limiting enzyme of polyamine biodegradation, in rabbit costal chondrocytes in culture. The enzyme activity increased in a dose-dependent manner after addition of PTH to the culture, reaching a maximum at 8 h. The increase in the enzyme activity was abolished by cycloheximide or actinomycin D. Dibutyryl cyclic AMP also induced the acetyltransferase to some extent. These results suggest that the induction of spermidine/spermine N1-acetyltransferase by PTH may play some significant role in the expression of the differentiated pheno-type of chondrocytes.
AB - Parathyroid hormone (PTH) increased the activity of spermidine/spermine N1-acetyltransferase, a rate-limiting enzyme of polyamine biodegradation, in rabbit costal chondrocytes in culture. The enzyme activity increased in a dose-dependent manner after addition of PTH to the culture, reaching a maximum at 8 h. The increase in the enzyme activity was abolished by cycloheximide or actinomycin D. Dibutyryl cyclic AMP also induced the acetyltransferase to some extent. These results suggest that the induction of spermidine/spermine N1-acetyltransferase by PTH may play some significant role in the expression of the differentiated pheno-type of chondrocytes.
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U2 - 10.1093/oxfordjournals.jbchem.a135066
DO - 10.1093/oxfordjournals.jbchem.a135066
M3 - Article
C2 - 2987201
AN - SCOPUS:0021910795
SN - 0021-924X
VL - 97
SP - 387
EP - 390
JO - Journal of Biochemistry
JF - Journal of Biochemistry
IS - 1
ER -