Infectious complications and managements for surgical site infections in genital Paget's disease

O. Yamasaki, K. Asagoe, M. Otsuka, Takashi Oono, Keiji Iwatsuki

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1 Citation (Scopus)


Background: Extramammary Paget's disease is an intra-epidermal carcinoma that occurs preferentially in genital areas. Patients with genital Paget's disease (GPD) sometimes develop severe post-surgical infections because of this anatomical disadvantage. Objective: To study perioperative micro-organisms and surgical site infection (SSI) in GPD. Methods: We examined micro-organisms isolated from preoperative lesions, necrotic sites and infected wounds in 60 adult patients with GPD who underwent surgery at our hospital between November 1990 and December 2005. Based on the obtained microbiological data, we assessed the incidence, risk factors and treatment of SSI. Results: The colonized organisms found in preoperative GPD were Enterobacteriaceae (27.6%), methicillin-sensitive Staphylococcus aureus (MSSA) (22.4%) and coagulase-negative staphylococci (CNS) (15.5%), among others. In the postoperative necrotic sites, the frequency of MSSA isolation was reduced to 9.4%, while Pseudomonas aeruginosa and methicillin-resistant S. aureus (MRSA) both increased in frequency from 3.4% and 0% upon preoperative examination to 18.8% and 9.4%, respectively. The incidence of SSI was 15%. In 7 of 9 SSIs, MRSA and/or P. aeruginosa were isolated. Conclusion: We have successfully identified a number of perioperative micro-organisms in GPD. The present observations may be extremely useful in choosing appropriate antimicrobial agents for use in the surgical treatment of GPD.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Issue number7
Publication statusPublished - Aug 2007


  • Antibiotic prophylaxis
  • Extramammary Paget's disease
  • Genitalia
  • Microflora
  • Surgical site infection

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases


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