TY - JOUR
T1 - Influence of breast density on breast cancer risk
T2 - a case control study in Japanese women
AU - Nishiyama, Keiko
AU - Taira, Naruto
AU - Mizoo, Taeko
AU - Kochi, Mariko
AU - Ikeda, Hirokuni
AU - Iwamoto, Takayuki
AU - Shien, Tadahiko
AU - Doihara, Hiroyoshi
AU - Ishihara, Setuko
AU - Kawai, Hiroshi
AU - Kawasaki, Kensuke
AU - Ishibe, Yoichi
AU - Ogasawara, Yutaka
AU - Toyooka, Shinichi
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research, Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Publisher Copyright:
© 2019, The Japanese Breast Cancer Society.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Background: Mammography is the standard examination for breast cancer screening of woman aged ≥ 40 years. High breast density on mammography indicates that mammary gland parenchyma occupy a high percentage of the breast. The objective of this study was to investigate factors associated with breast density and the risk of high breast density for breast cancer. Methods: A multicenter case–control study was performed in 530 patients and 1043 controls. Breast density was classified as C1–C4 using the Breast Imaging Reporting and Data System (BI-RADS). Clinical factors were obtained from questionnaires or medical records, and the influence of each factor (breast density, menopausal status, body mass index (BMI), parity, presence or absence of breastfeeding history, age at menarche, age at first birth, and familial history of breast cancer) on breast cancer risk in all patients was calculated as an age-adjusted odds ratio (OR). Multivariate logistic regression analyses were then performed in all patients and in pre- and postmenopausal and BMI-stratified groups using factors with a significant age-adjusted OR as adjustment factors. Results: Age-adjusted ORs for breast cancer were significant for breast density, BMI, parity, and breast feeding, but not for age at menarche, age at first birth, or family history of breast cancer. In multivariate analysis, there was a significant correlation between breast density and breast cancer in postmenopausal women (OR for C1 vs. C2 1.90 [95% CI 1.34–2.70]; C1 vs. C4 2.85 [95% CI 1.10–7.16]). This correlation was also significant in patients in the third BMI quartile (22.3–24.5 kg/m2) (OR for C1 vs. C4 8.76 [95% CI 2.38–42.47]); and fourth BMI quartile (>24.5 kg/m2) (OR for C1 vs. C2 1.92 [95% CI 1.17–3.15]; C1 vs. C4 11.89 [95% CI 1.56–245.17]). Conclusion: Breast density on mammography is a risk factor for breast cancer after adjustment for other risk factors. This risk is particularly high in postmenopausal women and those with a high BMI.
AB - Background: Mammography is the standard examination for breast cancer screening of woman aged ≥ 40 years. High breast density on mammography indicates that mammary gland parenchyma occupy a high percentage of the breast. The objective of this study was to investigate factors associated with breast density and the risk of high breast density for breast cancer. Methods: A multicenter case–control study was performed in 530 patients and 1043 controls. Breast density was classified as C1–C4 using the Breast Imaging Reporting and Data System (BI-RADS). Clinical factors were obtained from questionnaires or medical records, and the influence of each factor (breast density, menopausal status, body mass index (BMI), parity, presence or absence of breastfeeding history, age at menarche, age at first birth, and familial history of breast cancer) on breast cancer risk in all patients was calculated as an age-adjusted odds ratio (OR). Multivariate logistic regression analyses were then performed in all patients and in pre- and postmenopausal and BMI-stratified groups using factors with a significant age-adjusted OR as adjustment factors. Results: Age-adjusted ORs for breast cancer were significant for breast density, BMI, parity, and breast feeding, but not for age at menarche, age at first birth, or family history of breast cancer. In multivariate analysis, there was a significant correlation between breast density and breast cancer in postmenopausal women (OR for C1 vs. C2 1.90 [95% CI 1.34–2.70]; C1 vs. C4 2.85 [95% CI 1.10–7.16]). This correlation was also significant in patients in the third BMI quartile (22.3–24.5 kg/m2) (OR for C1 vs. C4 8.76 [95% CI 2.38–42.47]); and fourth BMI quartile (>24.5 kg/m2) (OR for C1 vs. C2 1.92 [95% CI 1.17–3.15]; C1 vs. C4 11.89 [95% CI 1.56–245.17]). Conclusion: Breast density on mammography is a risk factor for breast cancer after adjustment for other risk factors. This risk is particularly high in postmenopausal women and those with a high BMI.
KW - BMI
KW - Breast cancer
KW - Breast density
KW - Mammography
KW - Postmenopausal
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U2 - 10.1007/s12282-019-01018-6
DO - 10.1007/s12282-019-01018-6
M3 - Article
C2 - 31650498
AN - SCOPUS:85074386542
SN - 1340-6868
VL - 27
SP - 277
EP - 283
JO - Breast Cancer
JF - Breast Cancer
IS - 2
ER -
