Abstract
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naïve rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.
| Original language | English |
|---|---|
| Pages (from-to) | 271-274 |
| Number of pages | 4 |
| Journal | Acta medica Okayama |
| Volume | 58 |
| Issue number | 6 |
| Publication status | Published - Dec 1 2004 |
Keywords
- Animal model
- Depression
- Forced-swim test
- Imipramine
- Stress
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)