Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev

Satoshi Kubota, Rika Furuta, Masatoshi Maki, Masakazu Hatanaka

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

A nonfunctional mutant of human immunodeficiency virus type 1 Rev was created by deleting seven amino acid residues within the nucleolar targeting signal. This mutant Rev remained in the cytoplasm in expressed cells and strongly inhibited the function of Rev by interfering with the nuclear/nucleolar localization of coexpressed Rev. These findings strongly suggest the multimerization of Rev in the cytoplasm before migration to the nucleus/nucleolus, where wild-type Rev functions as a trans-regulator.

Original languageEnglish
Pages (from-to)2510-2513
Number of pages4
JournalJournal of Virology
Volume66
Issue number4
Publication statusPublished - Apr 1992
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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