TY - JOUR
T1 - Inhibitory effect of hemin on the mutagenic activities of carcinogens
AU - Arimoto, S.
AU - Negishi, Tomoe
AU - Hayatsu, H.
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare and a grant for Cancer Research from the Ministry of Education, Science and Culture.
PY - 1980
Y1 - 1980
N2 - An inhibitory effect of hemin on mutagenicities of a range of carcinogens was found by adding hemin to the preincubation mixture of the Ames' test. Strong inhibitions were observed for benzo[a]pyrene, 3-methylcholanthrene, 7,10-dimethylbenz[a]anthracene, chrysene, 2-acetylaminofluorene, 2-nitrofluorene and aflatoxin B1. Generally, 50% inhibition was caused by an amount of hemin 1–2 equivalents to the mutagen. Excess of hemin caused complete inhibitions. Hemin did not affect the mutagenicities of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-nitroquinoline-1-oxide, nitromin, N-methyl-N-nitrosourea, N-methyl-N′-nitro-N-nitrosoguanidine, N-nitrosodi-n-butyl-amine, quinoxaline-1,4-dioxide and carbadox. Biliverdin, bilirubin and chlorophyllin were also effective as inhibitors for the mutagenicity of benzo[a]pyrene.
AB - An inhibitory effect of hemin on mutagenicities of a range of carcinogens was found by adding hemin to the preincubation mixture of the Ames' test. Strong inhibitions were observed for benzo[a]pyrene, 3-methylcholanthrene, 7,10-dimethylbenz[a]anthracene, chrysene, 2-acetylaminofluorene, 2-nitrofluorene and aflatoxin B1. Generally, 50% inhibition was caused by an amount of hemin 1–2 equivalents to the mutagen. Excess of hemin caused complete inhibitions. Hemin did not affect the mutagenicities of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, 4-nitroquinoline-1-oxide, nitromin, N-methyl-N-nitrosourea, N-methyl-N′-nitro-N-nitrosoguanidine, N-nitrosodi-n-butyl-amine, quinoxaline-1,4-dioxide and carbadox. Biliverdin, bilirubin and chlorophyllin were also effective as inhibitors for the mutagenicity of benzo[a]pyrene.
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U2 - 10.1016/0304-3835(80)90125-1
DO - 10.1016/0304-3835(80)90125-1
M3 - Article
C2 - 7226136
AN - SCOPUS:0019162524
SN - 0304-3835
VL - 11
SP - 29
EP - 33
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
