Inhibitory effect of water-soluble chitosan on growth of Streptococcus mutans

M. Fujiwara, Y. Hayashi, N. Ohara

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


The present study was undertaken to evaluate the effects of pH and the degree of polymerization of chitosan on the inhibition of growth of Streptococcus mutans. Three types of chitosan, polymer, oligomer and monomer, were used at 4%(W/V) and three different levels of pH: 6.0, 6.5 and 7.4. Bactericidal activity was calculated by the growth ratio. Chitosan oligomer significantly inhibited bacterial growth at a pH value of 6.5. All three types of chitosan strongly inhibited bacterial growth at pH 6.0. Furthermore, nearly complete inhibition was obtained with 2%(W/V) chitosan solution at constant pH 6.5. This study is the first to report that water-soluble chitosan directly suppresses the growth of the typical cariogenic bacterium S. mutans even at pH 6.5, without causing demoralization of the tooth surface.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalNew Microbiologica
Issue number1
Publication statusPublished - Jan 2004
Externally publishedYes


  • Clinical application
  • Growth inhibition; caries prevention
  • Streptococcus mutans
  • Water-soluble chitosan
  • pH

ASJC Scopus subject areas

  • Microbiology (medical)


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