Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease

Jong Cheol Park; Jong Moon Hur; Ju Gwon Park; Tsutomu Hatano; Takashi Yoshida; Hirotsugu Miyashiro; Byung Sun Min; Masao Hattori

doi:10.1002/ptr.919

Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease

Jong Cheol Park, Jong Moon Hur, Ju Gwon Park, Tsutomu Hatano, Takashi Yoshida, Hirotsugu Miyashiro, Byung Sun Min, Masao Hattori

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

To identify substances with anti-human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC. Of the extracts tested, strong inhibitory effects were observed in the acetone extracts of the pericarp and leaves of Camellia japonica, the water extract of the leaves of Sageretia theezans and the methanol extract of the aerial part of Sophora flavescens. Camelliatannin H from the pericarp of C. japonica, showed a potent inhibitory activity on HIV-1 PR with IC₅₀ of 0.9 μM.

Original language	English
Pages (from-to)	422-426
Number of pages	5
Journal	Phytotherapy Research
Volume	16
Issue number	5
DOIs	https://doi.org/10.1002/ptr.919
Publication status	Published - Aug 1 2002

Keywords

Camellia japonica L.
Camelliatannin H
HIV-1 protease
Korean medicinal plants
Protease inhibitor

ASJC Scopus subject areas

Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ptr.919

Cite this

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title = "Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease",

abstract = "To identify substances with anti-human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC. Of the extracts tested, strong inhibitory effects were observed in the acetone extracts of the pericarp and leaves of Camellia japonica, the water extract of the leaves of Sageretia theezans and the methanol extract of the aerial part of Sophora flavescens. Camelliatannin H from the pericarp of C. japonica, showed a potent inhibitory activity on HIV-1 PR with IC50 of 0.9 μM.",

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AU - Park, Jong Cheol

AU - Hur, Jong Moon

AU - Park, Ju Gwon

AU - Hatano, Tsutomu

AU - Yoshida, Takashi

AU - Miyashiro, Hirotsugu

AU - Min, Byung Sun

AU - Hattori, Masao

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KW - HIV-1 protease

KW - Korean medicinal plants

KW - Protease inhibitor

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Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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