Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2

Yohei Takahashi; Takaaki Kubota; Sunao Yamamoto; Jun'Ichi Kobayashi

doi:10.1016/j.bmcl.2012.11.001

Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2

Yohei Takahashi, Takaaki Kubota, Sunao Yamamoto, Jun'Ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Metachromins are a series of sesquiterpenoid quinones isolated from Okinawan marine sponges. Inhibitory effects of metachromins L-Q (1-6), sesquiterpenoid quinones with an amino acid residue, and their related analogs (7-18) prepared from metachromins A (19) and C (20) against receptor tyrosine kinases EGFR and HER2 were investigated. Two analogs 11 and 12 showed relatively stronger inhibitory activity against EGFR, while metachromins L-Q (1-6) and seven analogs (8, 10, 11, and 15-18) showed inhibitory activities against HER2.

Original language	English
Pages (from-to)	117-118
Number of pages	2
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.bmcl.2012.11.001
Publication status	Published - Jan 1 2013
Externally published	Yes

Keywords

EGFR
HER2
Marine sponge
Metachromins
Spongia sp.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2012.11.001

Cite this

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title = "Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2",

abstract = "Metachromins are a series of sesquiterpenoid quinones isolated from Okinawan marine sponges. Inhibitory effects of metachromins L-Q (1-6), sesquiterpenoid quinones with an amino acid residue, and their related analogs (7-18) prepared from metachromins A (19) and C (20) against receptor tyrosine kinases EGFR and HER2 were investigated. Two analogs 11 and 12 showed relatively stronger inhibitory activity against EGFR, while metachromins L-Q (1-6) and seven analogs (8, 10, 11, and 15-18) showed inhibitory activities against HER2.",

keywords = "EGFR, HER2, Marine sponge, Metachromins, Spongia sp.",

author = "Yohei Takahashi and Takaaki Kubota and Sunao Yamamoto and Jun'Ichi Kobayashi",

note = "Funding Information: We thank Ms. S. Oka, Instrumental Analysis Division, Equipment Management Center, Creative Reseach Institution, Hokkaido University, for measurements of ESIMS. This work was supported by the Akiyama Life Sience Foundation, the Suhara Memorial Foundation, and Grant-in-Aid for Scientific Research on Innovative Areas (Biosynthetic Machinery) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan. ",

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doi = "10.1016/j.bmcl.2012.11.001",

language = "English",

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T1 - Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2

AU - Takahashi, Yohei

AU - Kubota, Takaaki

AU - Yamamoto, Sunao

AU - Kobayashi, Jun'Ichi

N1 - Funding Information: We thank Ms. S. Oka, Instrumental Analysis Division, Equipment Management Center, Creative Reseach Institution, Hokkaido University, for measurements of ESIMS. This work was supported by the Akiyama Life Sience Foundation, the Suhara Memorial Foundation, and Grant-in-Aid for Scientific Research on Innovative Areas (Biosynthetic Machinery) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Metachromins are a series of sesquiterpenoid quinones isolated from Okinawan marine sponges. Inhibitory effects of metachromins L-Q (1-6), sesquiterpenoid quinones with an amino acid residue, and their related analogs (7-18) prepared from metachromins A (19) and C (20) against receptor tyrosine kinases EGFR and HER2 were investigated. Two analogs 11 and 12 showed relatively stronger inhibitory activity against EGFR, while metachromins L-Q (1-6) and seven analogs (8, 10, 11, and 15-18) showed inhibitory activities against HER2.

AB - Metachromins are a series of sesquiterpenoid quinones isolated from Okinawan marine sponges. Inhibitory effects of metachromins L-Q (1-6), sesquiterpenoid quinones with an amino acid residue, and their related analogs (7-18) prepared from metachromins A (19) and C (20) against receptor tyrosine kinases EGFR and HER2 were investigated. Two analogs 11 and 12 showed relatively stronger inhibitory activity against EGFR, while metachromins L-Q (1-6) and seven analogs (8, 10, 11, and 15-18) showed inhibitory activities against HER2.

KW - EGFR

KW - HER2

KW - Marine sponge

KW - Metachromins

KW - Spongia sp.

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SN - 0960-894X

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EP - 118

JO - Bioorganic and Medicinal Chemistry Letters

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IS - 1

ER -

Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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