TY - JOUR
T1 - Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain
AU - Yamaguchi, Fuminori
AU - Itano, Toshifumi
AU - Mizobuchi, Masayuki
AU - Miyamoto, Osamu
AU - Jangua, Najma A.
AU - Matsui, Hideki
AU - Tokuda, Masaaki
AU - Ohmoto, Takashi
AU - Hosokawa, Kiyoshi
AU - Hatase, Osamu
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.
PY - 1990/11/19
Y1 - 1990/11/19
N2 - The regional distribution of insulin-like growth favtor I (IGF-I) was examined in the tissue and extracellular compartment of rat brain. The tissue content of IGF-I was the highest in the pituitary gland, followed by the olfactory bulb, upper brainstem, cerebellum, striatum, hippocampus, lower brainstem, and cerebral cortex. The extracellular concentration was studied by intracerebral microdialysis technique, and the highest content was found in the hippocampus, followed by the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. The tissue and extracellular contents were significantly correlated in the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. IGF-I might act by paracrine and/or autocrine regulatory mechanisms in these regions.
AB - The regional distribution of insulin-like growth favtor I (IGF-I) was examined in the tissue and extracellular compartment of rat brain. The tissue content of IGF-I was the highest in the pituitary gland, followed by the olfactory bulb, upper brainstem, cerebellum, striatum, hippocampus, lower brainstem, and cerebral cortex. The extracellular concentration was studied by intracerebral microdialysis technique, and the highest content was found in the hippocampus, followed by the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. The tissue and extracellular contents were significantly correlated in the olfactory bulb, hypothalamus, cerebellum, striatum, and cerebral cortex. IGF-I might act by paracrine and/or autocrine regulatory mechanisms in these regions.
KW - Autocrine
KW - Distribution
KW - Insulin-like growth factor I
KW - Intracerebral microdialysis
KW - Paracrine
KW - Rat brain
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U2 - 10.1016/0006-8993(90)91361-J
DO - 10.1016/0006-8993(90)91361-J
M3 - Article
C2 - 2289149
AN - SCOPUS:0025011776
SN - 0006-8993
VL - 533
SP - 344
EP - 347
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -