TY - JOUR
T1 - Interaction of Melatonin and BMP-6 in Ovarian Steroidogenesis
AU - Otsuka, Fumio
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (No. 24591364 and 15K09434), Foundation for Growth Science, Astellas Foundation for Research on Metabolic Disorders, Japan Foundation for Applied Enzymology (Japan), and The Uehara Memorial Foundation. I am grateful to Drs. Eri Nakamura, Takeshi Hosoya, Takayuki Hara, Motoshi Komatsubara, and Nahoko Iwata for their efforts in experiments.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018
Y1 - 2018
N2 - The bone morphogenetic protein (BMP) system in the ovary plays a physiological role as a luteinization inhibitor in growing follicles. BMP-6 secreted from oocytes and granulosa cells can exert an inhibitory effect on follicle-stimulating hormone (FSH) actions by suppressing adenylate cyclase activity downstream of the FSH receptor. The inhibition of FSH-induced progesterone production by BMP-6 is impaired by melatonin treatment in granulosa cells. Intracellular Smad signaling induced by BMP-6 is suppressed by melatonin, suggesting that melatonin has a regulatory role in BMP receptor signaling in granulosa cells. Since the expression of BMP-6 in granulosa cells is increased in patients with polycystic ovary syndrome, melatonin may play an important role in the maintenance of progesterone production by suppressing BMP-6 signaling, leading to the preservation of ovarian function.
AB - The bone morphogenetic protein (BMP) system in the ovary plays a physiological role as a luteinization inhibitor in growing follicles. BMP-6 secreted from oocytes and granulosa cells can exert an inhibitory effect on follicle-stimulating hormone (FSH) actions by suppressing adenylate cyclase activity downstream of the FSH receptor. The inhibition of FSH-induced progesterone production by BMP-6 is impaired by melatonin treatment in granulosa cells. Intracellular Smad signaling induced by BMP-6 is suppressed by melatonin, suggesting that melatonin has a regulatory role in BMP receptor signaling in granulosa cells. Since the expression of BMP-6 in granulosa cells is increased in patients with polycystic ovary syndrome, melatonin may play an important role in the maintenance of progesterone production by suppressing BMP-6 signaling, leading to the preservation of ovarian function.
KW - Bone morphogenetic protein
KW - Follicle-stimulating hormone
KW - Granulosa cells
KW - Melatonin
KW - Oocyte
KW - Steroidogenesis
UR - http://www.scopus.com/inward/record.url?scp=85041609368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041609368&partnerID=8YFLogxK
U2 - 10.1016/bs.vh.2018.01.012
DO - 10.1016/bs.vh.2018.01.012
M3 - Article
C2 - 29544628
AN - SCOPUS:85041609368
SN - 0083-6729
JO - Vitamins and Hormones
JF - Vitamins and Hormones
ER -