TY - JOUR
T1 - Internal distribution of micro- / Nano-sized inorganic particles and their cytocompatibility
AU - Abe, Shigeaki
AU - Iwadera, Nobuki
AU - Esaki, Mitsue
AU - Kida, Ikuhiro
AU - Mutoh, Mami
AU - Akasaka, Tsukasa
AU - Uo, Motohiro
AU - Yawaka, Yasutaka
AU - Morita, Manabu
AU - Haneda, Koichi
AU - Yonezawa, Tetsu
AU - Watari, Fumio
PY - 2011
Y1 - 2011
N2 - Nano-sized materials have received much attention lately, both in terms of their multiple applications and their biocompatibility. From both viewpoints, understanding the biodistribution of administered nano-materials is very important. In this study, we succeeded in visualizing the biodistribution of administered nano-materials using a scanning X-ray analytical microscope and magnetic resonance imaging method. Quantitative observation was carried out by inductively coupled plasma - atomic emission spectroscopy. We observed that the administered nano-particles accumulated in the liver, lung and spleen of mice. To estimate their cytocompatibility, the nano-particles were exposed to human liver cells. The results suggested that the micro-/ nano- particles have good cytocompatibility, except for copper oxide nano-particles.
AB - Nano-sized materials have received much attention lately, both in terms of their multiple applications and their biocompatibility. From both viewpoints, understanding the biodistribution of administered nano-materials is very important. In this study, we succeeded in visualizing the biodistribution of administered nano-materials using a scanning X-ray analytical microscope and magnetic resonance imaging method. Quantitative observation was carried out by inductively coupled plasma - atomic emission spectroscopy. We observed that the administered nano-particles accumulated in the liver, lung and spleen of mice. To estimate their cytocompatibility, the nano-particles were exposed to human liver cells. The results suggested that the micro-/ nano- particles have good cytocompatibility, except for copper oxide nano-particles.
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U2 - 10.1088/1757-899X/18/19/192013
DO - 10.1088/1757-899X/18/19/192013
M3 - Conference article
AN - SCOPUS:80052091720
SN - 1757-8981
VL - 18
JO - IOP Conference Series: Materials Science and Engineering
JF - IOP Conference Series: Materials Science and Engineering
IS - SYMPOSIUM 13
M1 - 192013
T2 - 3rd International Congress on Ceramics, ICC3
Y2 - 14 November 2010 through 18 November 2010
ER -