Internal distribution of micro- / Nano-sized inorganic particles and their cytocompatibility

Shigeaki Abe, Nobuki Iwadera, Mitsue Esaki, Ikuhiro Kida, Mami Mutoh, Tsukasa Akasaka, Motohiro Uo, Yasutaka Yawaka, Manabu Morita, Koichi Haneda, Tetsu Yonezawa, Fumio Watari

Research output: Contribution to journalConference articlepeer-review

10 Citations (Scopus)


Nano-sized materials have received much attention lately, both in terms of their multiple applications and their biocompatibility. From both viewpoints, understanding the biodistribution of administered nano-materials is very important. In this study, we succeeded in visualizing the biodistribution of administered nano-materials using a scanning X-ray analytical microscope and magnetic resonance imaging method. Quantitative observation was carried out by inductively coupled plasma - atomic emission spectroscopy. We observed that the administered nano-particles accumulated in the liver, lung and spleen of mice. To estimate their cytocompatibility, the nano-particles were exposed to human liver cells. The results suggested that the micro-/ nano- particles have good cytocompatibility, except for copper oxide nano-particles.

Original languageEnglish
Article number192013
JournalIOP Conference Series: Materials Science and Engineering
Issue numberSYMPOSIUM 13
Publication statusPublished - 2011
Event3rd International Congress on Ceramics, ICC3 - Osaka, Japan
Duration: Nov 14 2010Nov 18 2010

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)


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