Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

Masatoshi Uno; Takahiro Watanabe-Nakayama; Hiroki Konno; Ken ichi Akagi; Naotaka Tsutsumi; Toshiyuki Fukao; Masahiro Shirakawa; Hidenori Ohnishi; Hidehito Tochio

doi:10.1039/C8CC06480F

Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

Masatoshi Uno, Takahiro Watanabe-Nakayama, Hiroki Konno, Ken ichi Akagi, Naotaka Tsutsumi, Toshiyuki Fukao, Masahiro Shirakawa, Hidenori Ohnishi, Hidehito Tochio

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.

Original language	English
Pages (from-to)	12318-12321
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	87
DOIs	https://doi.org/10.1039/C8CC06480F
Publication status	Published - 2018
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/C8CC06480F

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abstract = "MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.",

author = "Masatoshi Uno and Takahiro Watanabe-Nakayama and Hiroki Konno and Akagi, {Ken ichi} and Naotaka Tsutsumi and Toshiyuki Fukao and Masahiro Shirakawa and Hidenori Ohnishi and Hidehito Tochio",

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T1 - Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

AU - Uno, Masatoshi

AU - Watanabe-Nakayama, Takahiro

AU - Konno, Hiroki

AU - Akagi, Ken ichi

AU - Tsutsumi, Naotaka

AU - Fukao, Toshiyuki

AU - Shirakawa, Masahiro

AU - Ohnishi, Hidenori

AU - Tochio, Hidehito

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018

Y1 - 2018

N2 - MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.

AB - MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.

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U2 - 10.1039/C8CC06480F

DO - 10.1039/C8CC06480F

M3 - Article

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EP - 12321

JO - Chemical Communications

JF - Chemical Communications

IS - 87

ER -

Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

Abstract

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