Abstract
This report describes a new therapeutic approach for severe ischemic heart disease, intramyocardial transplantation of autologous bone marrow-derived CD34 + cells combined with off-pump coronary artery bypass grafting (CABG). CD34 is widely known as a cell surface antigen expressed on hematopoietic stem cells, and recent experimental studies have shown that CD34 + cells include endothelial progenitor cells. We used the Isolex 300i magnetic cell selection system to separate CD34 + cells from bone marrow cells. This report describes the first case treated with the combination of off-pump CABG and cell transplantation for therapeutic angiogenesis and myocardial regeneration. The transplantation of autologous bone marrow-derived CD34 + cells improved perfusion of the ungraftable ischemic area.
| Original language | English |
|---|---|
| Pages (from-to) | E285-287 |
| Journal | The heart surgery forum |
| Volume | 7 |
| Issue number | 4 |
| Publication status | Published - 2004 |
ASJC Scopus subject areas
- Surgery
- Cardiology and Cardiovascular Medicine