TY - JOUR
T1 - Intravascular lymphomatosis of the skin as a manifestation of recurrent B-cell lymphoma
AU - Asagoe, Kenji
AU - Fujimoto, Wataru
AU - Yoshino, Tadashi
AU - Mannami, Tomohiko
AU - Liu, Yixuan
AU - Kanzaki, Hiroko
AU - Arata, Jirô
N1 - Funding Information:
This supplement is made possible through an unrestricted educational grant from Stiefel Laboratories to the American Academy of Dermatology.
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Intravascular lymphomatosis (IVL) is a rare type of lymphoma with a poor prognosis. Its distinctive clinical and histopathologic features are generated by the proliferation of neoplastic mononuclear cells within blood vessels. We describe a patient with IVL of the skin as a manifestation of a recurrent diffuse large B-cell lymphoma of ureteral origin. Lymphoma cells were located both within the vessels and the parenchyma in an early cutaneous lesion. After recurrence in the skin, lymphoma cells gradually located only in the vascular lumina. This transition suggests that cells localized within the vessels were selected as a consequence of chemotherapy. Immunohistochemical examination revealed that the expression of surface adhesion molecules of lymphoma cells did not significantly change. The results of polymerase chain reaction revealed that the ureteral and cutaneous tumors were identical in clonality. Our findings suggest that conventional diffuse large B-cell lymphoma can change into IVL.
AB - Intravascular lymphomatosis (IVL) is a rare type of lymphoma with a poor prognosis. Its distinctive clinical and histopathologic features are generated by the proliferation of neoplastic mononuclear cells within blood vessels. We describe a patient with IVL of the skin as a manifestation of a recurrent diffuse large B-cell lymphoma of ureteral origin. Lymphoma cells were located both within the vessels and the parenchyma in an early cutaneous lesion. After recurrence in the skin, lymphoma cells gradually located only in the vascular lumina. This transition suggests that cells localized within the vessels were selected as a consequence of chemotherapy. Immunohistochemical examination revealed that the expression of surface adhesion molecules of lymphoma cells did not significantly change. The results of polymerase chain reaction revealed that the ureteral and cutaneous tumors were identical in clonality. Our findings suggest that conventional diffuse large B-cell lymphoma can change into IVL.
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U2 - 10.1067/mjd.2003.112
DO - 10.1067/mjd.2003.112
M3 - Article
C2 - 12582370
AN - SCOPUS:0037327446
SN - 0190-9622
VL - 48
SP - S1-S4
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 2
ER -