Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions

Shuhei Naka, Kaoruko Wato, Taro Misaki, Seigo Ito, Yasuyuki Nagasawa, Ryota Nomura, Michiyo Matsumoto-Nakano, Kazuhiko Nakano

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background: IgA nephropathy (IgAN) is one of the most frequently occurring types of chronic glomerulonephritis. Previous analyses have revealed that a major pathogen of dental caries, Streptococcus mutans [which expresses collagen-binding protein (Cnm) on its surface], is involved in the pathogenesis of IgAN. Methods: Cnm-positive S. mutans isolated from a patient with IgAN was intravenously administered to specific pathogen-free Sprague–Dawley rats to evaluate their kidney conditions. Results: The urinary protein level of the S. mutans group reached a plateau at 30 days, with increased numbers of mesangial cells and an increased mesangial matrix. The numbers of rats with IgA-positive and/or C3-positive glomeruli were significantly greater in the S. mutans group than in the control group at 45 days (P < 0.05). Electron microscopy analyses revealed electron-dense depositions in the mesangial area among rats in the S. mutans group. There were significantly more CD68-positive cells (macrophages) in the glomeruli of the S. mutans group than in the glomeruli of the control group during the late phase (P < 0.05), similar to the findings in patients with IgAN. Conclusion: Our results suggested that intravenous administration of Cnm-positive S. mutans caused transient induction of IgAN-like lesions in rats.

Original languageEnglish
Pages (from-to)1122-1131
Number of pages10
JournalClinical and Experimental Nephrology
Issue number12
Publication statusPublished - Dec 1 2020


  • Dental caries
  • Glomerulonephritis
  • IgA nephropathy
  • Intravenous administration
  • Rats
  • Streptococcus mutans

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)


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