Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis

Yoshito Nishimura, Hideharu Hagiya, Kaoru Kawano, Yuya Yokota, Kosuke Oka, Koji Iio, Kou Hasegawa, Mikako Obika, Tomoko Haruma, Sawako Ono, Hisashi Masuyama, Fumio Otsuka

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2 Citations (Scopus)


Background: The widespread administration of the Haemophilus influenzae type b vaccine has led to the predominance of non-typable H. influenzae (NTHi). However, the occurrence of invasive NTHi infection based on gynecologic diseases is still rare. Case presentation: A 51-year-old Japanese woman with a history of adenomyoma presented with fever. Blood cultures and a vaginal discharge culture were positive with NTHi. With the high uptake in the uterus with 67Ga scintigraphy, she was diagnosed with invasive NTHi infection. In addition to antibiotic administrations, a total hysterectomy was performed. The pathological analysis found microabscess formations in adenomyosis. Conclusions: Although NTHi bacteremia consequent to a microabscess in adenomyosis is rare, this case emphasizes the need to consider the uterus as a potential source of infection in patients with underlying gynecological diseases, including an invasive NTHi infection with no known primary focus.

Original languageEnglish
Article number521
JournalBMC Infectious Diseases
Issue number1
Publication statusPublished - Jul 16 2020


  • Adenomyosis
  • Bacteremia
  • Case report
  • Non-typable Haemophilus influenzae
  • β-Lactamase-nonproducing ampicillin-resistance

ASJC Scopus subject areas

  • Infectious Diseases


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