TY - JOUR
T1 - Investigation of serum Cu, Zn-SOD concentration by ELISA and histological localization in hepatocellular carcinoma (HCC) using anti-human Cu, Zn-SOD monoclonal antibody
AU - Sakaida, Isao
AU - Ogino, Keiki
AU - Oka, Shinji
AU - Matsuura, Shinjiro
AU - Yoshimura, Shunji
AU - Matsuda, Kazuya
AU - Sasaki, Toshiyuki
AU - Yamamoto, Kasunari
AU - Ando, Keiiiro
AU - Fukumoto, Yohei
AU - Okita, Kiwamu
AU - Okazaki, Yukinori
AU - Takemoto, Tadayoshi
AU - Uda, Taizo
PY - 1987
Y1 - 1987
N2 - Serum Cu, Zn-SOD concentration and histological localization of patients with HCC were examined using anti-human Cu, Zn-SOD monoclonal antibody. The serum Cu, Zn-SOD concentration of patients with HCC was significantly elevated compared with healthy adults and also patients with liver cirrhosis but there was no correlation between serum Cu, Zn-SOD and serum GPT, GOT, AFP values. There are many reports that diminishing amounts of Cu, Zn-SOD activity were found in tumors, but our histological results show that in about 20% of our specimens Cu, Zn-SOD was strongly stained in tumors. This may indicae that amounts of Cu, Zn-SOD were quantitatively increased in tumors. These results suggest that it is possible for Cu, Zn-SOD to be a new marker for HCC and a possible reason for the existence of anti-cancer drug resistant HCC, for example such as adriamycin which kills the tumor cells mainly with active oxygen.
AB - Serum Cu, Zn-SOD concentration and histological localization of patients with HCC were examined using anti-human Cu, Zn-SOD monoclonal antibody. The serum Cu, Zn-SOD concentration of patients with HCC was significantly elevated compared with healthy adults and also patients with liver cirrhosis but there was no correlation between serum Cu, Zn-SOD and serum GPT, GOT, AFP values. There are many reports that diminishing amounts of Cu, Zn-SOD activity were found in tumors, but our histological results show that in about 20% of our specimens Cu, Zn-SOD was strongly stained in tumors. This may indicae that amounts of Cu, Zn-SOD were quantitatively increased in tumors. These results suggest that it is possible for Cu, Zn-SOD to be a new marker for HCC and a possible reason for the existence of anti-cancer drug resistant HCC, for example such as adriamycin which kills the tumor cells mainly with active oxygen.
UR - http://www.scopus.com/inward/record.url?scp=85007738446&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85007738446&partnerID=8YFLogxK
U2 - 10.2957/kanzo.28.1211
DO - 10.2957/kanzo.28.1211
M3 - Article
AN - SCOPUS:85007738446
SN - 0451-4203
VL - 28
SP - 1211
EP - 1218
JO - Kanzo
JF - Kanzo
IS - 9
ER -
